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KDELR3 抗体 (Middle Region)

kDELR3 适用: 人, 小鼠, 大鼠, Cow, 犬, 马, Pig, 兔, 豚鼠 WB 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN502774
发货至: 中国
  • 抗原 See all KDELR3 (kDELR3) 抗体
    KDELR3 (kDELR3) (KDEL (Lys-Asp-Glu-Leu) Endoplasmic Reticulum Protein Retention Receptor 3 (kDELR3))
    抗原表位
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    Middle Region
    适用
    • 16
    • 14
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    人, 小鼠, 大鼠, Cow, 犬, 马, Pig, 兔, 豚鼠
    宿主
    • 16
    克隆类型
    • 16
    多克隆
    标记
    • 9
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This KDELR3 antibody is un-conjugated
    应用范围
    • 9
    • 5
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB)
    序列
    AYVTVYMIYG KFRKTFDSEN DTFRLEFLLV PVIGLSFLEN YSFTLLEILW
    预测反应
    Cow: 100%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 92%, Pig: 100%, Rabbit: 100%, Rat: 93%
    产品特性
    This is a rabbit polyclonal antibody against KDELR3. It was validated on Western Blot using a cell lysate as a positive control.
    纯化方法
    Affinity Purified
    免疫原
    The immunogen is a synthetic peptide directed towards the middle region of human KDELR3
    Top Product
    Discover our top product kDELR3 Primary Antibody
  • 应用备注
    Optimal working dilutions should be determined experimentally by the investigator.
    说明

    Antigen size: 214 AA

    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    Lot specific
    缓冲液
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid repeated freeze-thaw cycles.
    储存条件
    -20 °C
    储存方法
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Collins, Wright, Edwards, Davis, Grinham, Cole, Goward, Aguado, Mallya, Mokrab, Huckle, Beare, Dunham: "A genome annotation-driven approach to cloning the human ORFeome." in: Genome biology, Vol. 5, Issue 10, pp. R84, (2004) (PubMed).

  • 抗原
    KDELR3 (kDELR3) (KDEL (Lys-Asp-Glu-Leu) Endoplasmic Reticulum Protein Retention Receptor 3 (kDELR3))
    别名
    KDELR3 (kDELR3 产品)
    别名
    ERD2L3 antibody, AI173274 antibody, ERD2 antibody, kdelr antibody, KDEL endoplasmic reticulum protein retention receptor 3 antibody, KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3 antibody, KDEL endoplasmic reticulum protein retention receptor 3 L homeolog antibody, KDELR3 antibody, Kdelr3 antibody, kdelr3.L antibody
    背景
    Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by their continual retrieval from the cis-Golgi, or a pre-Golgi compartment. Sorting of these proteins is dependent on a C-terminal tetrapeptide signal, usually lys-asp-glu-leu (KDEL) in animal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae. This process is mediated by a receptor that recognizes, and binds the tetrapeptide-containing protein, and returns it to the ER. In yeast, the sorting receptor encoded by a single gene, ERD2, is a seven-transmembrane protein. Unlike yeast, several human homologs of the ERD2 gene, constituting the KDEL receptor gene family, have been described. KDELR3 was the third member of the family to be identified, and it encodes a protein highly homologous to KDELR1 and KDELR2 proteins.Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by their continual retrieval from the cis-Golgi, or a pre-Golgi compartment. Sorting of these proteins is dependent on a C-terminal tetrapeptide signal, usually lys-asp-glu-leu (KDEL) in animal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae. This process is mediated by a receptor that recognizes, and binds the tetrapeptide-containing protein, and returns it to the ER. In yeast, the sorting receptor encoded by a single gene, ERD2, is a seven-transmembrane protein. Unlike yeast, several human homologs of the ERD2 gene, constituting the KDEL receptor gene family, have been described. KDELR3 was the third member of the family to be identified, and it encodes a protein highly homologous to KDELR1 and KDELR2 proteins. Two transcript variants of KDELR3 that arise by alternative splicing, and encode different isoforms of KDELR3 receptor, have been described.
    Alias Symbols: ERD2L3
    Protein Interaction Partner: UBC,
    Protein Size: 214
    分子量
    25 kDa
    基因ID
    11015
    NCBI登录号
    NM_006855, NP_006846
    UniProt
    O43731
    途径
    ER-Nucleus Signaling, Maintenance of Protein Location
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