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HNRNPU 抗体 (N-Term)

HNRNPU 适用: 人, 小鼠, 大鼠, Cow, 兔, 犬, 豚鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN501982
发货至: 中国
  • 抗原 See all HNRNPU 抗体
    HNRNPU (Heterogeneous Nuclear Ribonucleoprotein U (Scaffold Attachment Factor A) (HNRNPU))
    抗原表位
    • 15
    • 5
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    适用
    • 48
    • 40
    • 34
    • 9
    • 8
    • 6
    • 6
    • 5
    • 4
    • 3
    • 1
    • 1
    • 1
    人, 小鼠, 大鼠, Cow, 兔, 犬, 豚鼠
    宿主
    • 41
    • 7
    克隆类型
    • 32
    • 16
    多克隆
    标记
    • 27
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This HNRNPU antibody is un-conjugated
    应用范围
    • 39
    • 14
    • 10
    • 7
    • 6
    • 6
    • 6
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    序列
    NGAAGAADSG PMEEEEAASE DENGDDQGFQ EGEDELGDEE EGAGDENGHG
    预测反应
    Cow: 100%, Dog: 100%, Guinea Pig: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%
    产品特性
    This is a rabbit polyclonal antibody against HNRNPU. It was validated on Western Blot using a cell lysate as a positive control.
    纯化方法
    Affinity Purified
    免疫原
    The immunogen is a synthetic peptide directed towards the N terminal region of human HNRNPU
    Top Product
    Discover our top product HNRNPU Primary Antibody
  • 应用备注
    Optimal working dilutions should be determined experimentally by the investigator.
    说明

    Antigen size: 806 AA

    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    Lot specific
    缓冲液
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid repeated freeze-thaw cycles.
    储存条件
    -20 °C
    储存方法
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • 抗原
    HNRNPU (Heterogeneous Nuclear Ribonucleoprotein U (Scaffold Attachment Factor A) (HNRNPU))
    别名
    HNRNPU (HNRNPU 产品)
    别名
    AA408410 antibody, AI256620 antibody, AL024194 antibody, AL024437 antibody, AW557595 antibody, C86794 antibody, Hnrpu antibody, SAFA antibody, Sp120 antibody, hnRNP U antibody, SN1 antibody, HNRPU antibody, SAF-A antibody, U21.1 antibody, saf-a antibody, heterogeneous nuclear ribonucleoprotein U antibody, heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) S homeolog antibody, heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) antibody, Hnrnpu antibody, HNRNPU antibody, hnrnpu.S antibody
    背景
    HNRNPU belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. HNRNPU contains a RNA binding domain and scaffold-associated region (SAR)-specific bipartite DNA-binding domain. This protein is also thought to be involved in the packaging of hnRNA into large ribonucleoprotein complexes. During apoptosis, this protein is cleaved in a caspase-dependent way. But this cleavage does not affect the function of the encoded protein in RNA metabolism. This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they form complexes with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene contains a RNA binding domain and scaffold-associated region (SAR)-specific bipartite DNA-binding domain. This protein is also thought to be involved in the packaging of hnRNA into large ribonucleoprotein complexes. During apoptosis, this protein is cleaved in a caspase-dependent way. Cleavage occurs at the SALD site, resulting in a loss of DNA-binding activity and a concomitant detachment of this protein from nuclear structural sites. But this cleavage does not affect the function of the encoded protein in RNA metabolism. At least two alternatively spliced transcript variants have been identified for this gene.
    Alias Symbols: HNRPU, SAF-A, U21.1, hnRNP U
    Protein Interaction Partner: FBXW11, FUS, HUWE1, BTRC, UBC, TUBG1, TP53, AURKA, MAGED2, TUBGCP3, CEP57, AURKB, SUMO2, SUMO3, CEP70, CEP76, MDM2, LGALS3BP, EMD, HAUS2, TUBGCP4, CEP250, NEDD1, STAU1, IVNS1ABP, LGR4, ERG, RPA3, RPA2, RPA1, WWOX, RNF2, SHFM1, EED, rev, RPS29, RPS27, RPS6
    Protein Size: 806
    分子量
    89 kDa
    基因ID
    3192
    NCBI登录号
    NM_004501, NP_004492
    UniProt
    Q00839
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