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TOP2B 抗体 (Middle Region)

TOP2B 适用: 人, 小鼠, 大鼠, 犬, 马, 兔, 豚鼠, Cow WB 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN501630
发货至: 中国
  • 抗原 See all TOP2B 抗体
    TOP2B (Topoisomerase (DNA) II beta 180kDa (TOP2B))
    抗原表位
    • 15
    • 5
    • 5
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Middle Region
    适用
    • 47
    • 18
    • 17
    • 5
    • 4
    • 4
    • 3
    • 3
    • 3
    • 1
    • 1
    人, 小鼠, 大鼠, 犬, 马, 兔, 豚鼠, Cow
    宿主
    • 46
    • 2
    克隆类型
    • 46
    • 1
    多克隆
    标记
    • 23
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    This TOP2B antibody is un-conjugated
    应用范围
    • 19
    • 15
    • 14
    • 13
    • 13
    • 7
    • 7
    • 7
    • 5
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB)
    序列
    ENEGDYNPGR KTSKTTSKKP KKTSFDQDSD VDIFPSDFPT EPPSLPRTGR
    预测反应
    Cow: 92%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%
    产品特性
    This is a rabbit polyclonal antibody against TOP2B. It was validated on Western Blot using a cell lysate as a positive control.
    纯化方法
    Affinity Purified
    免疫原
    The immunogen is a synthetic peptide directed towards the middle region of human TOP2B
    Top Product
    Discover our top product TOP2B Primary Antibody
  • 应用备注
    Optimal working dilutions should be determined experimentally by the investigator.
    说明

    Antigen size: 1621 AA

    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    Lot specific
    缓冲液
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid repeated freeze-thaw cycles.
    储存条件
    -20 °C
    储存方法
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • 抗原
    TOP2B (Topoisomerase (DNA) II beta 180kDa (TOP2B))
    别名
    TOP2B (TOP2B 产品)
    别名
    TOP2B antibody, D230016L12Rik antibody, Top-2 antibody, TOPIIB antibody, top2beta antibody, DNA topoisomerase II beta antibody, topoisomerase (DNA) II beta antibody, microRNA 4442 antibody, TOP2B antibody, Top2b antibody, MIR4442 antibody
    背景
    TOP2B is a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia.This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, beta, is localized to chromosome 3 and the alpha form is localized to chromosome 17. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. Alternative splicing of this gene results in two transcript variants, however, the second variant has not yet been fully described. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
    Alias Symbols: TOPIIB, top2beta
    Protein Interaction Partner: BAZ1B, SUMO2, SUMO3, UBC, EIF6, RPA3, RPA2, RPA1, ERG, WHSC1, NOTCH1, ESR1, NCSTN, SNRNP200, RBM14, HNRNPR, HDAC3, XPC, TOP2A, SNRPE, SMARCE1, SMARCD2, SMARCC2, SMARCC1, SMARCB1, SMARCA4, SMARCA2, SFPQ, S100A9, MSH2, IK, SEPT7, SUMO1, CUL5, NEDD8, RANBP2,
    Protein Size: 1621
    分子量
    183 kDa
    基因ID
    7155
    NCBI登录号
    NM_001068, NP_001059
    UniProt
    Q02880
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