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Tuberin 抗体 (C-Term)

TSC2 适用: 人, 小鼠 WB, EIA 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN501073
发货至: 中国
  • 抗原 See all Tuberin (TSC2) 抗体
    Tuberin (TSC2) (Tuberous Sclerosis 2 (TSC2))
    抗原表位
    • 29
    • 22
    • 20
    • 19
    • 16
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    • 2
    • 1
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    • 1
    • 1
    • 1
    C-Term
    适用
    • 291
    • 194
    • 124
    • 8
    • 6
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    人, 小鼠
    宿主
    • 383
    • 12
    克隆类型
    • 374
    • 21
    多克隆
    标记
    • 144
    • 35
    • 33
    • 31
    • 24
    • 24
    • 11
    • 11
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    • 10
    • 10
    • 7
    • 7
    • 7
    • 7
    • 7
    • 1
    • 1
    • 1
    • 1
    • 1
    This Tuberin antibody is un-conjugated
    应用范围
    • 212
    • 183
    • 125
    • 81
    • 80
    • 66
    • 36
    • 34
    • 20
    • 12
    • 9
    • 6
    • 6
    • 4
    • 2
    Western Blotting (WB), Enzyme Immunoassay (EIA)
    特异性
    This antibody detects Tuberin / TSC2 at C-term.
    交叉反应 (详细)
    Species reactivity (tested):Human, mouse
    纯化方法
    Peptide affinity chromatography
    免疫原
    TSC2 antibody was raised against a 15 amino acid peptide from near the carboxy-terminus of human TSC2.
    亚型
    IgG
    Top Product
    Discover our top product TSC2 Primary Antibody
  • 应用备注
    ELISA. Western blot: 1 μg/mL.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    限制
    仅限研究用
  • 缓冲液
    PBS containing 0.02 % sodium azide
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid repeated freezing and thawing.
    储存条件
    4 °C/-20 °C
    储存方法
    Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
  • 抗原
    Tuberin (TSC2) (Tuberous Sclerosis 2 (TSC2))
    别名
    Tuberin / TSC2 (TSC2 产品)
    别名
    TSC2 antibody, fc16b02 antibody, tuberin antibody, wu:fc16b02 antibody, LAM antibody, TSC4 antibody, Nafld antibody, Tcs2 antibody, Rc antibody, TSC complex subunit 2 antibody, tuberin antibody, hypothetical protein antibody, tuberous sclerosis 2 antibody, TSC2 antibody, LOC5569538 antibody, tsc2 antibody, PGTG_00159 antibody, Tsc2 antibody
    背景
    Tuberous sclerosis complex (TSC) is an autosomal dominant tumor syndrome caused by mutations in either of the TSC1 or TSC2 tumor suppressor genes. The products of these genes form a protein complex that indirectly decreases the signaling of the mammalian Target of Rapamycin (TOR), an evolutionarily conserved serine/threonine kinase that regulates cell growth and cell cycle through its ability to integrate signals from nutrient levels and growth factors (reviewed in 1,2). TOR activity is stimulated by Rheb, a member of the Ras superfamily of G-proteins, when the GTP/GDP ratio bound to Rheb is high (3). Immunoprecipitated TSC1/TSC2 has been shown to stimulate Rheb GTPase activity in vitro (4), suggesting that the TSC1/TSC2 complex decreases the ability of Rheb to stimulate TOR activity. This is supported by experiments showing that overexpression of TSC1 and TSC2 results in a significant decrease in the GTP/GDP ratio bound to Rheb and the inhibition of cell growth (4,5). At least three isoforms of TSC2 exist.Synonyms: TSC4, Tuberous sclerosis 2 protein
    基因ID
    7249
    NCBI登录号
    NP_000539
    途径
    RTK signaling, AMPK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Cell Size, Tube Formation, Protein targeting to Nucleus
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