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MARCH8 抗体 (C-Term)

MARCH8 适用: 人, 小鼠, 大鼠 WB, IF, EIA 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN500234
发货至: 中国
  • 抗原 See all MARCH8 抗体
    MARCH8 (Membrane-Associated Ring Finger (C3HC4) 8, E3 Ubiquitin Protein Ligase (MARCH8))
    抗原表位
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    适用
    • 30
    • 26
    • 25
    • 8
    • 5
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    人, 小鼠, 大鼠
    宿主
    • 29
    • 1
    克隆类型
    • 30
    多克隆
    标记
    • 11
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This MARCH8 antibody is un-conjugated
    应用范围
    • 30
    • 13
    • 5
    • 4
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)
    特异性
    This antibody detects MARCH8.
    交叉反应 (详细)
    Species reactivity (tested):Human, mouse, rat
    纯化方法
    Peptide affinity chromatography
    免疫原
    MARCH8 antibody was raised against a 17 amino acid peptide from near the carboxy terminus of human MARCH8.
    亚型
    IgG
    Top Product
    Discover our top product MARCH8 Primary Antibody
  • 应用备注
    ELISA. Western blot: 0.5 - 1 μg/mL. Immunocytochemistry.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    限制
    仅限研究用
  • 缓冲液
    PBS containing 0.02 % sodium azide
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid repeated freezing and thawing.
    储存条件
    4 °C/-20 °C
    储存方法
    Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
  • 抗原
    MARCH8 (Membrane-Associated Ring Finger (C3HC4) 8, E3 Ubiquitin Protein Ligase (MARCH8))
    别名
    MARCH8 (MARCH8 产品)
    别名
    MARCH-VIII antibody, MIR antibody, RNF178 antibody, c-MIR antibody, zgc:171495 antibody, 1300017E09Rik antibody, Mir antibody, Mar-08 antibody, MARCH8 antibody, membrane associated ring-CH-type finger 8 antibody, membrane-associated ring finger (C3HC4) 8 antibody, membrane associated ring-CH-type finger 8 L homeolog antibody, MARCH8 antibody, march8 antibody, March8 antibody, march8.L antibody
    背景
    MARCH8 (c-MIR) is a novel E3 ubiquitin ligase designated as the modulator of immune recognition (MIR) family, whose catalytic domain is a variant RING domain (RING-CH domain). MARCH8 was found as a functional and structural homolog of KSHV MIR1 and MIR2. MARCH8 targets B7-2 to lysosomal degradation and down-regulates the B7-2 surface expression through ubiquitination of its cytoplasmic tail. Furthermore, MARCH8 has been shown to down-regulate the expression of transferrin receptor and Fas, an important molecule for the induction of apoptosis. MARCH8 is the first example of an E3 ubiquitin ligase that is capable of inhibiting MHC II expression. Recent findings suggest that MARCH8 may regulate immune responses by promoting ubiquitination of MHC-II and CD86, leading to their subsequent endocytosis and lysosomal degradation.Synonyms: Cellular modulator of immune recognition, E3 ubiquitin-protein ligase MARCH8, MARCH-VIII, Membrane-associated RING finger protein 8, RING finger protein 178, RNF178, c-MIR
    基因ID
    220972
    NCBI登录号
    NP_659458
    UniProt
    Q5T0T0
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