DcR2 抗体 (Intracellular)
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- 抗原 See all DcR2 (TNFRSF10D) 抗体
- DcR2 (TNFRSF10D) (Tumor Necrosis Factor Receptor Superfamily, Member 10d, Decoy with Truncated Death Domain (TNFRSF10D))
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抗原表位
- AA 249-263, Intracellular
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适用
- 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This DcR2 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)
- 特异性
- DcR2 antibody was raised against a peptide corresponding to amino acids 249 to 263 of Human DcR2 precursor.
- 纯化方法
- Affinity Chromatography purified via peptide column
- 免疫原
- Human DcR2 (Intracellular Domain) Peptide corresponding to amino acids 249 to 263 of Human DcR2 precursor.
- 亚型
- IgG
- Top Product
- Discover our top product TNFRSF10D Primary Antibody
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- 应用备注
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ELISA. Western Blot: 1/1000 to 1/2000. Immunocytochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - 限制
- 仅限研究用
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- 缓冲液
- PBS containing 0.02 % Sodium Azide as preservative
- 储存液
- Sodium azide
- 注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C
- 储存方法
- Store the antibody undiluted at 2-8 °C.
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Combining an Aurora Kinase Inhibitor and a Death Receptor Ligand/Agonist Antibody Triggers Apoptosis in Melanoma Cells and Prevents Tumor Growth in Preclinical Mouse Models." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 21, Issue 23, pp. 5338-48, (2015) (PubMed).
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Combining an Aurora Kinase Inhibitor and a Death Receptor Ligand/Agonist Antibody Triggers Apoptosis in Melanoma Cells and Prevents Tumor Growth in Preclinical Mouse Models." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 21, Issue 23, pp. 5338-48, (2015) (PubMed).
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- 抗原
- DcR2 (TNFRSF10D) (Tumor Necrosis Factor Receptor Superfamily, Member 10d, Decoy with Truncated Death Domain (TNFRSF10D))
- 别名
- CD264 / TRAILR4 (TNFRSF10D 产品)
- 别名
- TNFRSF10D antibody, CD264 antibody, DCR2 antibody, TRAIL-R4 antibody, TRAILR4 antibody, TRUNDD antibody, TNF receptor superfamily member 10d antibody, tumor necrosis factor receptor superfamily member 10D antibody, TNFRSF10D antibody, LOC716901 antibody
- 背景
- Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. TRAIL/Apo2L is a new member of the TNF family and induces apoptosis of a variety of tumor cell lines. DR4 and DR5 are the recently identified functional receptors for TRAIL, and DcR1/TRID is a decoy receptor (1-3). Another member of the TRAIL receptor family was more recently identified and designated DcR2, TRAIL-R4, or TRUNDD (4-6). DcR2 has an extracellular TRAIL-binding domain but lacks intracellular death domain and does not induce apoptosis. Like DR4 and DR5, DcR2 transcript is widely expressed in normal human tissues. Overexpression of DcR2 attenuated TRAIL-induced apoptosis.Synonyms: DCR2, Decoy receptor 2, TNF-related apoptosis-inducing ligand receptor 4, TNFRSF10D, TRAIL receptor 4, TRAIL receptor with a truncated death domain, TRAIL-R4, TRUNDD, Tumor necrosis factor receptor superfamily member 10D
- 基因ID
- 8793
- UniProt
- Q9UBN6
- 途径
- Apoptosis
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