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- 抗原 See all DACT3 products
- DACT3 (Dapper, Antagonist of beta-Catenin, Homolog 3 (DACT3))
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抗原表位
- N-Term
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适用
- 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This DACT3 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Enzyme Immunoassay (EIA)
- 特异性
- This antibody reacts to DACT3.
- 纯化方法
- Affinity chromatography purified via peptide column
- 免疫原
- Dact3 antibody was raised against a 17 amino acid peptide from near the amino terminus of human Dact3.
- 亚型
- IgG
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anti-Dapper, Antagonist of beta-Catenin, Homolog 3 (DACT3) (AA 1-160) antibody
DACT3 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Dapper, Antagonist of beta-Catenin, Homolog 3 (DACT3) antibodyDACT3 适用: 人, 小鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Dapper, Antagonist of beta-Catenin, Homolog 3 (DACT3) (AA 255-304) antibodyDACT3 适用: 人, Pig, Cow, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Dapper, Antagonist of beta-Catenin, Homolog 3 (DACT3) (AA 399-448) antibodyDACT3 适用: 人, Pig, 猴 WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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ELISA. Western Blot: 1 - 2 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - 限制
- 仅限研究用
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- 缓冲液
- PBS containing 0.02 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C
- 储存方法
- Store the antibody undiluted at 2-8 °C.
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- 抗原
- DACT3 (Dapper, Antagonist of beta-Catenin, Homolog 3 (DACT3))
- 别名
- DACT3 (DACT3 产品)
- 别名
- EG666671 antibody, naa-3 antibody, DAPPER3 antibody, RRR1 antibody, RGD1563892 antibody, dishevelled binding antagonist of beta catenin 3 antibody, dishevelled-binding antagonist of beta-catenin 3 antibody, DACT3 antibody, Dact3 antibody
- 背景
- The Wnt signaling cascade is a conserved process in multicellular animals that plays important roles during development and can contribute to cancer and other diseases. Many members of this pathway are also expressed in the postnatal tissues such as brain. One such protein is Dact3, a member of the Dact protein family that was initially identified through binding to Disheveled (Dvl), a cytoplasmic protein essential to Wnt signaling. Dact3 is expressed in the ventral region of maturing somites, limb bud and branchial arch mesenchyme, embryonic CNS, and the adult brain. Recent evidence shows that Dact3 acts as a negative regulator Wnt/b-catenin signaling that is repressed at the transcriptional level in colorectal cancer and this repression is associated with bivalent histone modifications. This repression can be reversed by pharmacological agents that targets both histone methylation and deacetylation, suggesting that Dact3 may be a potential target for therapeutic treatment of this cancer. At least three isoforms of Dact3 are known to exist.Synonyms: DAPPER3, RRR1, antagonist of beta-catenin dapper homolog 3, arginine-rich region 1 protein, dapper homolog 3
- 基因ID
- 147906
- UniProt
- Q96B18
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