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DACT2 抗体 (N-Term)

DACT2 适用: 人, 小鼠, 大鼠 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN499702
发货至: 中国
  • 抗原 See all DACT2 抗体
    DACT2 (Dapper, Antagonist of beta-Catenin 2 (DACT2))
    抗原表位
    • 1
    • 1
    N-Term
    适用
    人, 小鼠, 大鼠
    宿主
    • 1
    克隆类型
    • 1
    多克隆
    标记
    • 1
    This DACT2 antibody is un-conjugated
    应用范围
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    特异性
    This antibody reacts to DACT2.
    纯化方法
    Affinity chromatography purified via peptide column
    免疫原
    Dact2 antibody was raised against a 12 amino acid peptide from near the amino terminus of human DACT2.
    亚型
    IgG
  • 应用备注
    ELISA. Western Blot: 1 - 2 μg/mL. Immunohistochemistry.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    限制
    仅限研究用
  • 缓冲液
    PBS containing 0.02 % sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C
    储存方法
    Store the antibody undiluted at 2-8 °C.
  • Tan, Li, Huang, Cheng, Zhao, Chen, Chen, Tang, Zhang, Huang, Cheng: "Upregulation of DACT2 suppresses proliferation and enhances apoptosis of glioma cell via inactivation of YAP signaling pathway." in: Cell death & disease, Vol. 8, Issue 8, pp. e2981, (2018) (PubMed).

    Zhao, Herman, Brock, Sheng, Zhang, Liu, Guo: "Methylation of DACT2 promotes papillary thyroid cancer metastasis by activating Wnt signaling." in: PLoS ONE, Vol. 9, Issue 11, pp. e112336, (2015) (PubMed).

  • 抗原
    DACT2 (Dapper, Antagonist of beta-Catenin 2 (DACT2))
    别名
    DACT2 (DACT2 产品)
    别名
    2900084M21Rik antibody, A630024E20 antibody, Dpr2 antibody, Frd2 antibody, dapper2 antibody, C6orf116 antibody, DAPPER2 antibody, DPR2 antibody, RP11-503C24.7 antibody, bA503C24.7 antibody, dishevelled binding antagonist of beta catenin 2 antibody, dishevelled-binding antagonist of beta-catenin 2 antibody, DACT2 antibody, Dact2 antibody
    背景
    The Wnt signaling cascade is a conserved process in multicellular animals that plays important roles during development and can contribute to cancer and other diseases. Many members of this pathway are also expressed in the postnatal tissues such as brain. One such protein is Dact2, a member of the Dact protein family that was initially identified through binding to Disheveled (Dvl), a cytoplasmic protein essential to Wnt signaling. Dact2 is most prominent during the development of the thymus kidneys, and salivary gland. Dact2 is thought to play a role distinct from that of Dact1 with Dact2 having a greater impact on a b-catenin-independent process termed planar cell polarity/convergent-extension signaling. Furthermore, Dact2 but not Dact1 can inhibit Nodal signaling by promoting the endocytic degradation of TGF-b receptors. At least two isoforms of Dact2 are known to exist.Synonyms: C6orf116, DAPPER2, DPR2, PP13671, dapper homolog 2
    基因ID
    168002
    NCBI登录号
    NP_999627
    UniProt
    Q5SW24
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