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Caspase 12 抗体 (small)

CASP12 适用: 人, 小鼠, 大鼠 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN499553
发货至: 中国
  • 抗原 See all Caspase 12 (CASP12) 抗体
    Caspase 12 (CASP12) (Caspase 12 (Gene/pseudogene) (CASP12))
    抗原表位
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    small
    适用
    人, 小鼠, 大鼠
    宿主
    • 88
    • 3
    • 1
    克隆类型
    • 89
    • 3
    多克隆
    标记
    • 39
    • 8
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    This Caspase 12 antibody is un-conjugated
    应用范围
    • 78
    • 40
    • 29
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    • 26
    • 20
    • 19
    • 10
    • 6
    • 5
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    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    特异性
    Caspase-12 antibody was raised against a synthetic peptide corresponding to amino acids within the small cleavage product of murine caspase-12.
    纯化方法
    Affinity chromatography purified via peptide column
    免疫原
    Human Caspase-12 (Small) Peptide
    亚型
    IgG
    Top Product
    Discover our top product CASP12 Primary Antibody
  • 应用备注
    ELISA. Western Blot: Caspase-12 (small) antibody can be used for the detection of both thepropeptide and cleaved forms of caspase-12 at 0.5 to 2 μg/mL. Immunohistochemistry.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    限制
    仅限研究用
  • 缓冲液
    PBS containing 0.02 % sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C
    储存方法
    Store the antibody undiluted at 2-8 °C.
  • 抗原
    Caspase 12 (CASP12) (Caspase 12 (Gene/pseudogene) (CASP12))
    别名
    Caspase-12 (CASP12 产品)
    别名
    Caspase-12 antibody, CASP-12 antibody, CASP12P1 antibody, caspase 12 antibody, caspase 12 (gene/pseudogene) antibody, Casp12 antibody, CASP12 antibody
    背景
    Three distinct signaling pathways lead to programmed cell death (apoptosis). The death receptor and mitochondrion pathways are the main, in which the key apoptotic proteases capase-8 and caspase-9, respectively, are involved. The endoplasmic reticulum (ER) stress is the third apoptotic pathway and caspase-12 is involved (1,2). Caspase-12 is localized to the ER but not to cytoplasm or mitochondrion. Caspase-12 is activated by ER stress, including disruption of ER calcium homeostasis, and mediates ER stress-induced apoptosis. Caspase-12 is co-localized to the ER with several proteins that are involved in Alzheimer's disease including gamma-secretase presenilin and beta-amyloid precursor protein (APP). Caspase-12 mediates cytotoxicity induced by amyloid-beta. Caspase-12 is ubiquitously expressed in mouse tissues (1).Synonyms: CASP-12, CASP12, Inactive caspase-12
    基因ID
    100044205
    UniProt
    O08736
    途径
    Apoptosis, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Unfolded Protein Response
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