PTRH2 抗体 (Middle Region)
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- 抗原 See all PTRH2 抗体
- PTRH2 (Peptidyl-tRNA Hydrolase 2 (PTRH2))
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抗原表位
- Middle Region
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适用
- 人, 小鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This PTRH2 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
- 特异性
- Bit1 antibody was raised against a 16 amino acid peptide from near the center of human Bit1.
- 纯化方法
- Affinity chromatography purified via peptide column
- 免疫原
- Human Bit1 / Bcl-2 inhibitor of transcription 1 / Peptidyl-tRNA hydrolase 2 (Intermediate Domain) Peptide
- 亚型
- IgG
- Top Product
- Discover our top product PTRH2 Primary Antibody
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anti-Peptidyl-tRNA Hydrolase 2 (PTRH2) (AA 40-179) antibody
PTRH2 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Peptidyl-tRNA Hydrolase 2 (PTRH2) (AA 42-178) antibodyPTRH2 适用: 人 WB, IF, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Peptidyl-tRNA Hydrolase 2 (PTRH2) (AA 40-179) antibodyPTRH2 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Peptidyl-tRNA Hydrolase 2 (PTRH2) (AA 26-55), (N-Term) antibodyPTRH2 适用: 人 WB 宿主: 兔 Polyclonal RB42733 unconjugated
anti-Peptidyl-tRNA Hydrolase 2 (PTRH2) (AA 100-149) antibodyPTRH2 适用: 人, 豚鼠, 马, Cow, 犬, 猴, Pig WB 宿主: 兔 Polyclonal unconjugated
anti-Peptidyl-tRNA Hydrolase 2 (PTRH2) (AA 80-110) antibodyPTRH2 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB06095 unconjugated
anti-Peptidyl-tRNA Hydrolase 2 (PTRH2) antibodyPTRH2 适用: 人, 小鼠, 大鼠 WB, IF, IC 宿主: 兔 Polyclonal unconjugated
anti-Peptidyl-tRNA Hydrolase 2 (PTRH2) (N-Term) antibodyPTRH2 适用: 人, 小鼠, 大鼠 WB, IF, EIA 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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ELISA. Western Blot: Bit1 antibody can be used for the detection of Bit1 at 1 - 2 μg/mL. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - 限制
- 仅限研究用
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- 缓冲液
- PBS containing 0.02 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C
- 储存方法
- Store the antibody undiluted at 2-8 °C.
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- 抗原
- PTRH2 (Peptidyl-tRNA Hydrolase 2 (PTRH2))
- 别名
- PTRH2 / BIT1 (PTRH2 产品)
- 别名
- BIT1 antibody, PTH2 antibody, A230072I16Rik antibody, Bit1 antibody, CGI-147 antibody, wu:fj09f02 antibody, zgc:109954 antibody, RGD1306819 antibody, peptidyl-tRNA hydrolase 2 antibody, ptrh2 antibody, CC1G_10259 antibody, ANI_1_1036184 antibody, AOR_1_2082154 antibody, PTRH2 antibody, Ptrh2 antibody
- 背景
- Adhesion to extracellular matrix regulates cell survival through both integrin engagement and appropriate cell spreading. Anoikis is the molecular mechanism of apop-tosis induced by integrin detachment (1). Bit1 (Bcl-2 inhibitor of transcription 1) was recently identified as being involved in this process (2). Bit1 is a mitochondrial protein that is released into the cytoplasm upon onset of apoptosis where it forms a complex with AES, a small Groucho/transducin-like enhancer of split (TLE) protein and induces caspase-independent apoptosis. Both AES and TLE proteins are transcriptional co-repressors that play important roles in neurogenesis, segmentation, and sex determination (3). It has been suggested that Bit1-AES complexes turn off a survival-promoting gene transcription program controlled by TLE (2). Interestingly, apoptosis of cells transfected with Bit1 and AES could be inhibited if the cells were allowed to attach to fibronectin through the alpha5beta1 integrin suggesting that the Bit1-AES pathway contributing to anoikis is regulated by integrins, and in particular, the alpha5beta1 integrin (2).Synonyms: CGI-147, PTH2, Peptidyl-tRNA hydrolase 2 mitochondrial
- 基因ID
- 51651
- NCBI登录号
- NP_057161
- UniProt
- Q9Y3E5
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