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AMBRA1 抗体 (C-Term)

AMBRA1 适用: 人, 小鼠, 大鼠 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN499271
发货至: 中国
  • 抗原 See all AMBRA1 抗体
    AMBRA1 (Autophagy/beclin-1 Regulator 1 (AMBRA1))
    抗原表位
    • 21
    • 15
    • 5
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    适用
    • 40
    • 28
    • 12
    • 1
    • 1
    人, 小鼠, 大鼠
    宿主
    • 54
    • 1
    克隆类型
    • 54
    • 1
    多克隆
    标记
    • 15
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This AMBRA1 antibody is un-conjugated
    应用范围
    • 47
    • 13
    • 13
    • 13
    • 11
    • 10
    • 9
    • 8
    • 4
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    特异性
    This antibody reacts to AMBRA1.
    纯化方法
    Affinity chromatography purified via peptide column
    免疫原
    Ambra1 antibody was raised against a 15 amino acid peptide from near the carboxy terminus of human Ambra1.
    亚型
    IgG
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    Discover our top product AMBRA1 Primary Antibody
  • 应用备注
    ELISA. Western Blot: Ambra1 antibody can be used for the detection of Ambra1 at 1 - 2 μg/mL. Immunohistochemistry.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    限制
    仅限研究用
  • 缓冲液
    PBS containing 0.02 % sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C
    储存方法
    Store the antibody undiluted at 2-8 °C.
  • 抗原
    AMBRA1 (Autophagy/beclin-1 Regulator 1 (AMBRA1))
    别名
    AMBRA1 (AMBRA1 产品)
    别名
    2310079H06Rik antibody, A130023A14 antibody, AA474864 antibody, AV021921 antibody, D030051N19Rik antibody, mKIAA1736 antibody, Nyw1 antibody, DCAF3 antibody, WDR94 antibody, autophagy and beclin 1 regulator 1 antibody, autophagy/beclin-1 regulator 1a antibody, autophagy/beclin 1 regulator 1 antibody, AMBRA1 antibody, ambra1a antibody, Ambra1 antibody
    背景
    Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components. Beclin-1, a principal regulator of autophagosome formation, is in turn regulated by Ambra1. Ambra1 associates with Beclin-1 through a region near its center as determined by yeast two-hybrid assay. Null mutations in this gene in mice resulted in embryonic lethality with severe neural tube defects associated with autophagy impairment, accumulation of ubiquitinated proteins, unbalanced cell proliferation and excessive apoptotic death . Furthermore, down-regulation of Ambra1 in cultured cells though RNA interference decreased the level of rapamycin- and nutrient starvation-induced autophagy. Multiple isoforms of Ambra1 are known to exist.Synonyms: Activating molecule in BECN1-regulated autophagy protein 1, KIAA1736
    基因ID
    55626
    UniProt
    Q9C0C7
    途径
    Autophagy
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