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AICDA 抗体 (C-Term)

AICDA 适用: 人, 小鼠 WB, IF, EIA 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN499233
发货至: 中国
  • 抗原 See all AICDA 抗体
    AICDA (Activation-Induced Cytidine Deaminase (AICDA))
    抗原表位
    • 15
    • 6
    • 6
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    适用
    • 42
    • 13
    • 6
    • 2
    • 1
    人, 小鼠
    宿主
    • 36
    • 3
    • 2
    • 1
    克隆类型
    • 38
    • 4
    多克隆
    标记
    • 25
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This AICDA antibody is un-conjugated
    应用范围
    • 37
    • 19
    • 13
    • 13
    • 6
    • 6
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)
    特异性
    This antibody recognizes AID (C-term).
    纯化方法
    Affinity chromatography purified via peptide column
    免疫原
    A Peptide corresponding to 14 amino acids near the carboxy-terminus of Human AID
    亚型
    IgG
    Top Product
    Discover our top product AICDA Primary Antibody
  • 应用备注
    ELISA. Western Blot: AID antibody can be used for detection of AID at 1 - 2 μg/mL. Whole cell lysatefrom Ramos cells can be used as positive control. Immunocytochemistry.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    限制
    仅限研究用
  • 缓冲液
    PBS containing 0.02 % Sodium Azide as preservative
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid repeated freezing and thawing.
    储存条件
    4 °C/-20 °C
    储存方法
    Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Milillo, Molinario, Costanzi, Vischini, La Carpia, La Greca, Rigante, Gambaro, Gurrieri, Sangiorgi: "Defective activation of the MAPK/ERK pathway, leading to PARP1 and DNMT1 dysregulation, is a common defect in IgA nephropathy and Henoch-Schönlein purpura." in: Journal of nephrology, Vol. 31, Issue 5, pp. 731-741, (2018) (PubMed).

  • 抗原
    AICDA (Activation-Induced Cytidine Deaminase (AICDA))
    别名
    AICDA / AID (AICDA 产品)
    别名
    AID antibody, ARP2 antibody, CDA2 antibody, HIGM2 antibody, Aid antibody, Arp2 antibody, aid antibody, AICDA antibody, arp2 antibody, cda2 antibody, higm2 antibody, xlaid antibody, activation induced cytidine deaminase antibody, activation-induced cytidine deaminase antibody, activation-induced cytidine deaminase L homeolog antibody, AICDA antibody, Aicda antibody, aicda antibody, aicda.L antibody
    背景
    Activation-induced cytidine deaminase (AID) was initially discovered as a homolog of the apolipoprotein B RNA-editing cytidine deaminase 1 (APOBEC1) that showed cytidine deaminase properties in stimulated B cell lines (1). It is necessary for somatic hypermutation and class switch recombination in B cells (2), but inappropriate or dysregulated expression AID is often found in tumors and B cell neoplasms (2,3). Although it is structurally and functionally similar to the APOBEC proteins (reviewed in 4), it appears unlikely that AID deaminates dC to dU residues in HIV cDNA as does APOBEC3G (5).Synonyms: Activation-induced cytidine deaminase, Cytidine aminohydrolase
    基因ID
    57379
    NCBI登录号
    NP_065712
    UniProt
    Q9GZX7
    途径
    Cellular Response to Molecule of Bacterial Origin, Regulation of Actin Filament Polymerization, Production of Molecular Mediator of Immune Response
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