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Acetylated Lysine 抗体

WB, ELISA, IP, IHC, IF, ICC 宿主: 小鼠 Monoclonal 7F8 unconjugated
产品编号 ABIN488677
发货至: 中国
  • 抗原 See all Acetylated Lysine products
    Acetylated Lysine
    适用
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    宿主
    • 29
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    小鼠
    克隆类型
    • 27
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    单克隆
    标记
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    This Acetylated Lysine antibody is un-conjugated
    应用范围
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    Western Blotting (WB), ELISA, Immunoprecipitation (IP), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
    特异性
    The antibody detects proteins containing acetylated lysine residues in ELISA and WBs. Does not detect non-acetylated lysine residues.
    交叉反应 (详细)
    Not reactive in: no confirmed exceptions from predicted reactivity known in the moment
    预测反应
    higher plants
    纯化方法
    affinity purified
    免疫原
    acetylated KLH
    克隆位点
    7F8
    亚型
    IgG1
  • 应用备注
    1: 100 (IHC), 1: 1000 (WB), for other assays optimal dilution has to be determined by end user
    说明

    1 µg of this antibody is sufficient to detect acetylated chicken erythrocyte histones (sodium butyrate-treated) using 20 µg total protein and ECL detection system

    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    protein G purified IgG2B in PBS, pH 7.4 with 0.09 % sodium azide and 50 %glycerol at concentration 1 mg/mL
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid repeated freeze-thaw cycles.
    Please, remember to spin tubes briefly prior to opening them to avoid any losses that might occur from lyophilized material adhering to the cap or sides of the tubes.
    储存条件
    -20 °C
    储存方法
    store at -20°C, avoid repeated freeze-thaw cycles. Please, remember to spin tubes briefly prior to opening them to avoid any losses that might occur from lyophilized material adhering to the cap or sides of the tubes.
  • 抗原
    Acetylated Lysine
    Abstract
    Acetylated Lysine 产品
    别名
    C-K-RAS antibody, CFC2 antibody, K-RAS2A antibody, K-RAS2B antibody, K-RAS4A antibody, K-RAS4B antibody, KI-RAS antibody, KRAS1 antibody, KRAS2 antibody, NS antibody, NS3 antibody, RASK2 antibody, KRAS proto-oncogene, GTPase antibody, KRAS antibody
    物质类
    Chemical
    背景
    Post-translational modifications of proteins play critical roles in the regulation and function of many known biological processes. Proteins can be post-translationally modified in many different ways, and a common posttranscriptional modification of Lysine involves acetylation (1). The conserved amino-terminal domains of the four core histones (H2A, H2B, H3 and H4) contain lysines that are acetylated by histone acetyltransferases (HATs) and deacetylated by histone deacetylases (HDACs) (2). Protein posttranslational reversible lysine Nε-acetylation and deacetylation have been recognized as an emerging intracellular signaling mechanism that plays critical roles in regulating gene transcription, cell-cycle progression, apoptosis, DNA repair, and cytoskeletal organization (3).
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