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GDF15 抗体 (C-Term)

GDF15 适用: 人, 小鼠, 大鼠, Chimpanzee, Macaque WB, EIA 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN453961
发货至: 中国
  • 抗原 See all GDF15 抗体
    GDF15 (Growth Differentiation Factor 15 (GDF15))
    抗原表位
    • 18
    • 15
    • 11
    • 8
    • 7
    • 5
    • 5
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    适用
    人, 小鼠, 大鼠, Chimpanzee, Macaque
    宿主
    • 86
    • 12
    • 3
    • 1
    克隆类型
    • 86
    • 15
    • 1
    多克隆
    标记
    • 53
    • 15
    • 9
    • 8
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This GDF15 antibody is un-conjugated
    应用范围
    • 87
    • 54
    • 36
    • 16
    • 13
    • 13
    • 9
    • 7
    • 6
    • 5
    • 3
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), Enzyme Immunoassay (EIA)
    特异性
    This antibody reacts with the C-terminus of endogenous NAG-1 protein.
    交叉反应 (详细)
    Species reactivity (expected):Chimpanzee, Macaque, Mouse, Rat.
    Species reactivity (tested):Human.
    纯化方法
    Affinity chromatography
    免疫原
    Synthetic peptide corresponding to the C-terminal sequence of NAG-1 protein. A residue of cysteine was added to facilitate coupling
    亚型
    IgG
    Top Product
    Discover our top product GDF15 Primary Antibody
  • 应用备注
    ELISA: 1/300,000. Western Blot: 2,000 - 10,000.
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1.0 mg/mL (by UV absorbance at 280 nm)
    缓冲液
    0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 containing 0.09 % (w/v) Sodium
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid repeated freezing and thawing.
    储存条件
    -20 °C
  • 抗原
    GDF15 (Growth Differentiation Factor 15 (GDF15))
    别名
    GDF15 (GDF15 产品)
    别名
    GDF15 antibody, GDF-15 antibody, MIC-1 antibody, MIC1 antibody, NAG-1 antibody, PDF antibody, PLAB antibody, PTGFB antibody, SBF antibody, growth differentiation factor 15 antibody, GDF15 antibody, Gdf15 antibody
    背景
    The non-steroidal antiinflammatory drug (NSAID) activated gene (NAG-1) is a member of the transforming growth factor-beta (TGF-beta) superfamily. NAG-1 is also known as Macrophage Inhibitory Cytokine-1 (MIC-1), Growth Differentiation Factor 15 (GDF15), Placental Bone Morphogenetic Protein (PLAB), or Prostate Derived Factor (PDF). NAG-1 is expressed in human placenta, prostate and colon. It possesses antitumorigenic and proapoptotic activities. NAG-1 expression is dramatically increased in inflammation, injury and malignancy. Increase of NAG-1 expression is a feature of many cancers including breast, colon, pancreas and prostate. In a number of studies, NAG-1 expression was increased by a number of NSAIDs. This increase in expression may correlate with the chemopreventive effect NSAIDs seem to have with certain cancers. NAG-1 expression is also induced by PPAR gamma ligands and by several dietary compounds such as conjugated linoleic acids (CLAs), naturally occurring fatty acids in ruminant food products, indoles, epicatechin gallate, and genistein. The induced expression of NAG-1 results in a stimulation of apoptosis and inhibition of cell growth. Inhibition of NAG-1 induced expression by small interference RNA (siRNA) results in repression of induced apoptosis. NAG-1 expression is regulated by a numbers of transcription factors such as ERG-1 and Sp1. EGR-1 may be necessary for NSAID-induced NAG-1 expression. The study of expression of NAG-1 proteins, including variants, is important to define their potential role as serum biomarkers for cancer diagnosis, treatment monitoring, epidemiology study, and nutrition surveys.Synonyms: GDF-15, Growth/differentiation factor 15, MIC-1, MIC1, Macrophage inhibitory cytokine 1, NAG-1, NRG-1, NSAID-activated gene 1 protein, NSAID-regulated gene 1 protein, PDF, PLAB, PTGFB, Placental TGF-beta, Placental bone morphogenetic protein, Prostate differentiation factor
    基因ID
    9518
    NCBI登录号
    NP_004855
    UniProt
    Q99988
    途径
    SARS-CoV-2 Protein Interactome
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