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HSF1 抗体

HSF1 适用: 人, 小鼠, 大鼠, Cow, 兔, 猴, 豚鼠, Hamster WB, IP, IF, EIA, EMSA 宿主: 大鼠 Monoclonal 10H8 unconjugated
产品编号 ABIN453930
发货至: 中国
  • 抗原 See all HSF1 抗体
    HSF1 (Heat Shock Factor Protein 1 (HSF1))
    适用
    • 193
    • 109
    • 57
    • 13
    • 11
    • 10
    • 7
    • 7
    • 6
    • 4
    • 4
    • 1
    • 1
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    • 1
    人, 小鼠, 大鼠, Cow, 兔, 猴, 豚鼠, Hamster
    宿主
    • 179
    • 33
    • 7
    • 1
    大鼠
    克隆类型
    • 168
    • 51
    单克隆
    标记
    • 118
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    • 10
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    • 8
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    • 2
    This HSF1 antibody is un-conjugated
    应用范围
    • 183
    • 111
    • 85
    • 66
    • 48
    • 44
    • 30
    • 28
    • 28
    • 28
    • 9
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    • 1
    Western Blotting (WB), Immunoprecipitation (IP), Immunofluorescence (IF), Enzyme Immunoassay (EIA), Electrophoretic Mobility-Shift Assay (EMSA)
    特异性
    This antibody detects an ~85 kDa protein in unstressed cell lysates, and an ~95 kDa protein in heat shocked cell lysates, corresponding to the molecular mass of inactive and active forms of HSF1 on SDS-PAGE immunoblots.
    交叉反应 (详细)
    Species reactivity (tested):Human, Mouse, Rat, Bovine, Guinea pig, Hamster, Monkey, Rabbit
    产品特性
    Synonyms: HSTF1, HSF-1, Heat shock transcription factor 1
    纯化方法
    Purified
    免疫原
    Purified recombinant HSF1 protein
    克隆位点
    10H8
    亚型
    IgG1
    Top Product
    Discover our top product HSF1 Primary Antibody
  • 应用备注
    Western blot (see ref.1). Immunoprecipitation. Immunocytochemistry (see ref.1). ELISA (see ref.1). Gel Mobility Shift Assay (see ref.1).
    限制
    仅限研究用
  • 浓度
    1.0 mg/mL
    缓冲液
    PBS, pH 7.4, 0.09 % sodium azide in 50 % glycerol
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C/-20 °C
    储存方法
    Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C. Avoid repeated freezing andthawing.
    Shelf life: one year from despatch.
    有效期
    12 months
  • 抗原
    HSF1 (Heat Shock Factor Protein 1 (HSF1))
    别名
    Heat Shock Factor 1 / HSF1 (HSF1 产品)
    别名
    hsf1 antibody, Hsf antibody, xhsf1 antibody, AA960185 antibody, HSTF1 antibody, HSF1 antibody, HSF antibody, HSF1c antibody, hsf1a antibody, hsf1b antibody, zHSF1a antibody, zHSF1b antibody, hstf1 antibody, heat shock factor antibody, Heat Shock Factor antibody, heat shock factor 1 antibody, heat shock transcription factor 1 antibody, heat shock transcription factor 1 S homeolog antibody, hsf1 antibody, hsf-1 antibody, Hsf1 antibody, HSF1 antibody, hsf1.S antibody
    背景
    HSF1, or heat shock factor 1, belongs to a family of Heat Shock transcription factors that activate the transcription of genes encoding products required for protein folding, processing, targeting, degradation, and function (2). The up-regulation of HSP (heat shock proteins) expression by stressors is achieved at the level of transcription through a heat shock element (HSE) and a transcription factor (HSF) (3, 4, 5). Most HSFs have highly conserved amino acid sequences. On all HSFs there is a DNA binding domain at the Nterminus. Hydrophobic repeats located adjacent to this binding domain are essential for the formation of active trimers. Towards the C-terminal region another short hydrophobic repeat exists, and is thought to be necessary for suppression of trimerization (6). There are two main heat shock factors, 1 and 2. Mouse HSF1 exists as two isoforms, however in higher eukaryotes HSF1 is found in a diffuse cytoplasmic and nuclear distribution in un-stressed cells. Once exposed to a multitude of stressors, it localizes to discrete nuclear granules within seconds. As it recovers from stress, HSF1 dissipates from these granules to a diffuse nuceloplasmic distribution. HSF2 on the other hand is similar to mouse HSF1, as it exists as two isoforms, the alpha form being more transciptionally active than the smaller beta form (7, 8). Various experiments have suggested that HFS2 may have roles in differentiation and development (9, 10, 11).Synonyms: HSF-1, HSTF1, Heat shock transcription factor 1
    基因ID
    3297
    UniProt
    Q00613
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