TRKA 抗体 (Neurotrophic Tyrosine Kinase, Receptor, Type 1) (Tyr791)

Details for Product anti-NTRK1 Antibody No. ABIN453859, 供应商: Log in to see
抗原
  • trk
  • trka
  • TRKA
  • MTC
  • TRK
  • TRK1
  • Trk-A
  • p140-TrkA
  • C80751
  • Tkr
  • TrkA
  • Trk
  • CTRKA
  • trkA
  • CAPM1
  • CFTD
  • NEM1
  • OK/SW-cl.5
  • TM-5
  • TM3
  • TM30
  • TM30nm
  • TM5
  • TPMsk3
  • hscp30
  • neurotrophic tyrosine kinase, receptor, type 1
  • tropomyosin 3
  • ntrk1
  • NTRK1
  • LOC100354292
  • Ntrk1
  • TPM3
抗原表位
Tyr791
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适用

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宿主

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克隆类型
多克隆
标记
This TRKA antibody is un-conjugated
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应用范围
Enzyme Immunoassay (EIA), Western Blotting (WB)
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选项
Supplier
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免疫原 KLH conjugated synthetic peptide selected from the Y791 region of human TrkA
特异性 This antibody reacts to TrkA pTyr791.
纯化方法 Affinity chromatography on Protein A
别名 TrkA (NTRK1 Antibody 摘要)
背景 TRKA (also known as NTRK1)is a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in the TRKA gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer.Synonyms: High affinity nerve growth factor receptor, NTRK1, Neurotrophic tyrosine kinase receptor type 1, TRK, TRK1-transforming tyrosine kinase protein, Trk-A, p140-TrkA
基因ID 4914
NCBI登录号 NP_001007793
UniProt P04629
研究领域 Cancer
途径 RTK signaling, Neurotrophin Signaling Pathway, cAMP Metabolic Process
应用备注 ELISA: 1/1,000. Western blotting: 1/100 - 1/500.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
限制 仅限研究用
状态 Liquid
浓度 0.25 mg/mL
缓冲液 PBS with 0.09 % (W/V) sodium azide
储存液 Sodium azide
注意事项 This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
注意事项 Avoid repeated freezing and thawing.
储存条件 4 °C/-20 °C
储存方法 Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
厂商提供的图像
Western Blotting (WB) image for anti-Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1) (Tyr791) antibody (ABIN453859) Western blot analysis of hTrkA-pY791 in HepG2 cell line lysates (35ug/lane). TRK (arr...
背景 Tokusashi, Asai, Tamakawa, Yamamoto, Yoshie, Yaginuma, Miyokawa, Aoki, Kino, Kasai, Ogawa: "Expression of NGF in hepatocellular carcinoma cells with its receptors in non-tumor cell components." in: International journal of cancer. Journal international du cancer, Vol. 114, Issue 1, pp. 39-45, 2005 (PubMed).

Schulte, Schramm, Klein-Hitpass, Klenk, Wessels, Hauffa, Eils, Eils, Brodeur, Schweigerer, Havers, Eggert: "Microarray analysis reveals differential gene expression patterns and regulation of single target genes contributing to the opposing phenotype of TrkA- and TrkB-expressing neuroblastomas." in: Oncogene, Vol. 24, Issue 1, pp. 165-77, 2005 (PubMed).

Frattini, Ferrario, Bressan, Balestra, De Cecco, Mondellini, Bongarzone, Collini, Gariboldi, Pilotti, Pierotti, Greco: "Alternative mutations of BRAF, RET and NTRK1 are associated with similar but distinct gene expression patterns in papillary thyroid cancer." in: Oncogene, Vol. 23, Issue 44, pp. 7436-40, 2004 (PubMed).

Tacconelli, Farina, Cappabianca, Desantis, Tessitore, Vetuschi, Sferra, Rucci, Argenti, Screpanti, Gulino, Mackay: "TrkA alternative splicing: a regulated tumor-promoting switch in human neuroblastoma." in: Cancer cell, Vol. 6, Issue 4, pp. 347-60, 2004 (PubMed).

Flørenes, Maelandsmo, Holm, Reich, Lazarovici, Davidson: "Expression of activated TrkA protein in melanocytic tumors: relationship to cell proliferation and clinical outcome." in: American journal of clinical pathology, Vol. 122, Issue 3, pp. 412-20, 2004 (PubMed).

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