LAMP1 抗体
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- 抗原 See all LAMP1 抗体
- LAMP1 (Lysosomal-Associated Membrane Protein 1 (LAMP1))
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适用
- 大鼠, Hamster
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This LAMP1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunoprecipitation (IP), Immunofluorescence (IF)
- 特异性
- This antibody detects an ~120 kDa protein corresponding to the molecular mass of LAMP1 on SDS-PAGE immunoblots.
- 交叉反应 （详细）
- Species reactivity (tested):Rat, Hamster
- 产品特性
- Synonyms: LAMP-1, LAMPA, LGP120, Lysosome-associated membrane glycoprotein 1, CD107Antigen-like Family Member A
- 纯化方法
- Purified
- 免疫原
- Rat liver lysosomal membrane preparations
- 克隆位点
- Ly1C6
- 亚型
- IgG1
- Top Product
- Discover our top product LAMP1 Primary Antibody
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anti-Lysosomal-Associated Membrane Protein 1 (LAMP1) (AA 301-417) antibody
LAMP1 适用: 人, 小鼠, 大鼠, 猴 WB, FACS, ELISA, ICC, IHC (p), IHC (fro), IF (cc), IF (p) 宿主: 兔 Polyclonal unconjugated
anti-Lysosomal-Associated Membrane Protein 1 (LAMP1) (AA 49-297) antibodyLAMP1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Lysosomal-Associated Membrane Protein 1 (LAMP1) antibodyLAMP1 适用: 人, 小鼠, Non-Human Primate WB, FACS, ICC, IHC (p), IHC (fro) 宿主: 小鼠 Monoclonal H4A3 unconjugated
anti-Lysosomal-Associated Membrane Protein 1 (LAMP1) antibodyLAMP1 适用: 大鼠 WB, IP, IF, ICC 宿主: 小鼠 Monoclonal Ly1C6 unconjugated
anti-Lysosomal-Associated Membrane Protein 1 (LAMP1) (AA 125-154) antibodyLAMP1 适用: 人, 小鼠 WB, IHC, IF, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Lysosomal-Associated Membrane Protein 1 (LAMP1) antibodyLAMP1 适用: 人, 小鼠, 灵长类 WB, FACS, IHC, ICC, IHC (p), IHC (fro) 宿主: 小鼠 Monoclonal H4A3 unconjugated
anti-Lysosomal-Associated Membrane Protein 1 (LAMP1) antibody (FITC)LAMP1 适用: 小鼠 WB, FACS, IHC, IP, IHC (p), IHC (fro) 宿主: 大鼠 Monoclonal FITC
anti-Lysosomal-Associated Membrane Protein 1 (LAMP1) antibody (APC)LAMP1 适用: 人, 小鼠, Non-Human Primate FACS 宿主: 小鼠 Monoclonal H4A3 APC
anti-Lysosomal-Associated Membrane Protein 1 (LAMP1) antibodyLAMP1 适用: 人, Green Monkey WB, IF, IHC (p) 宿主: 小鼠 Monoclonal 3C3 unconjugated
anti-Lysosomal-Associated Membrane Protein 1 (LAMP1) antibody (FITC)LAMP1 适用: 大鼠 WB, IP, IF, ICC 宿主: 小鼠 Monoclonal Ly1C6 FITC
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- 应用备注
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Western blot (6): 1 μg/mL. Immunoprecipitation (5). Immunflourescence (1).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - 限制
- 仅限研究用
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- 浓度
- 1.0 mg/mL
- 缓冲液
- PBS pH 7.4, 0.09 % azide, in 50 % glycerol
- 储存液
- Sodium azide
- 注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C/-20 °C
- 储存方法
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Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer. Avoidrepeated freezing and thawing.
Shelf life: one year from despatch. - 有效期
- 12 months
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- 抗原
- LAMP1 (Lysosomal-Associated Membrane Protein 1 (LAMP1))
- 别名
- CD107a / LAMP1 (LAMP1 产品)
- 背景
- Lysosme associated membrane proteins, or LAMP1 and LAMP2, are major constituents of the lysosomal membrane. The two have closely related structures, with 37 % sequence homology (2). They are both transmembrane glycoproteins that are localized primarily in lysosomes and late endosomes. Newly synthesized molecules are mostly transported from the trans-Golgi network directly to endosomes and then to lysosomes. A second pathway involves the lamps being delivered from the Golgi to the cell surface, and then along the endocytic pathway to the lysosomes. A minor pathway involves transport via the plasma membrane (3). Upon stimulation, a rapid translocation of intracellular LAMPs to the cell membrane is dependent on a carboxylterminal tyrosine based motif (YXXI) (1). If there is a disturbance in this spacing, lysosome localization of LAMP1 is abolished and the mutant protein then cycles between the membrane and the endosome (3). This stimulation has also been shown to have an associated release of histamine, leukotriene C (4) and prostaglandin D (2), which shows that LAMP-1 and LAMP-2 are activation markers for normal mast cells (1). They have also been linked to the inflammatory response in that they promote adhesion of human peripheral blood mononuclear cells (PBMC) to vascular endothelium, and therefore possibly the adhesion of PBMC to the site of inflammation (4).Synonyms: CD107 Antigen-like Family Member A, LAMP-1, LAMPA, LGP120, Lysosome-associated membrane glycoprotein 1
- 基因ID
- 25328
- UniProt
- P14562
- 途径
- Autophagy
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