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TRKA 抗体 (pSer791)

NTRK1 适用: 人 IF 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN401581
发货至: 中国
  • 抗原 See all TRKA (NTRK1) 抗体
    TRKA (NTRK1) (Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1))
    抗原表位
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    pSer791
    适用
    • 239
    • 151
    • 144
    • 15
    • 4
    • 4
    • 1
    • 1
    宿主
    • 248
    • 15
    • 3
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    克隆类型
    • 240
    • 27
    • 1
    多克隆
    标记
    • 102
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    This TRKA antibody is un-conjugated
    应用范围
    • 185
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    Immunofluorescence (IF)
    特异性
    Antibody AP09480PU detects endogenous levels of TrkA only when phosphorylated at Tyrosine 791.
    纯化方法
    Immunoaffinity Chromatography using epitope-specific phosphopeptide.
    免疫原
    The antiserum was produced against synthesized phosphopeptide derived from human TrkA around the phosphorylation site of tyrosine791 (P-V-Yp-L-D).
    Top Product
    Discover our top product NTRK1 Primary Antibody
  • 应用备注
    Immunofluorescence: 1/100approx. 1/200.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    限制
    仅限研究用
  • 浓度
    1.0 mg/mL
    缓冲液
    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % Sodium Azide and 50 % Glycerol.
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid repeated freezing and thawing.
    储存条件
    -20 °C
    储存方法
    Store the antibody (in aliquots) at-20 °C.
  • 抗原
    TRKA (NTRK1) (Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1))
    别名
    TrkA (NTRK1 产品)
    别名
    MTC antibody, TRK antibody, TRK1 antibody, TRKA antibody, Trk-A antibody, p140-TrkA antibody, CDHF12 antibody, CDHR16 antibody, HSCR1 antibody, MEN2A antibody, MEN2B antibody, MTC1 antibody, PTC antibody, RET-ELE1 antibody, RET51 antibody, Trk antibody, C80751 antibody, Tkr antibody, TrkA antibody, trk antibody, trka antibody, CTRKA antibody, trkA antibody, neurotrophic receptor tyrosine kinase 1 antibody, ret proto-oncogene antibody, neurotrophic tyrosine kinase, receptor, type 1 antibody, NTRK1 antibody, RET antibody, Ntrk1 antibody, ntrk1 antibody
    背景
    The Trk proto-oncogene family contains four members, TrkA, TrkB, TrkC, and TrkE, which are variably expressed throughout the central and peripheral nervous systems. TrkA binds to nerve growth factor (NGF) and autophosphorylates on tyrosine residues (Tyr490, Tyr674, Tyr675, Tyr751 and Tyr785) to activate multiple downstream effector proteins. Phosphorylation at Tyr490 is required for Shc association and subsequent activation of the Ras-MAP kinase-signaling cascade, which leads to activation of Elk-1-dependent gene transcription and neurite growth. Phosphorylations at Tyr674 and Tyr675 lie within the catalytic domain of TrkA tyrosine kinase and reflect Trk kinase activity. Additionally, phosphorylation at Tyr751 is required for PI3-kinase association and activation of the Akt signaling cascade.Synonyms: High affinity nerve growth factor receptor, NTRK1, Neurotrophic tyrosine kinase receptor type 1, TRK, TRK1-transforming tyrosine kinase protein, Trk-A, p140-TrkA
    基因ID
    4914
    NCBI登录号
    NP_001007793
    UniProt
    P04629
    途径
    RTK signaling, Neurotrophin Signaling Pathway, cAMP Metabolic Process
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