TRKA 抗体 (Neurotrophic Tyrosine Kinase, Receptor, Type 1) (pSer791)

Details for Product anti-NTRK1 Antibody No. ABIN401580, 供应商: Log in to see
抗原
  • trk
  • trka
  • TRKA
  • MTC
  • TRK
  • TRK1
  • Trk-A
  • p140-TrkA
  • C80751
  • Tkr
  • TrkA
  • Trk
  • CTRKA
  • trkA
  • CAPM1
  • CFTD
  • NEM1
  • OK/SW-cl.5
  • TM-5
  • TM3
  • TM30
  • TM30nm
  • TM5
  • TPMsk3
  • hscp30
  • neurotrophic tyrosine kinase, receptor, type 1
  • tropomyosin 3
  • ntrk1
  • NTRK1
  • LOC100354292
  • Ntrk1
  • TPM3
抗原表位
pSer791
58
26
23
19
18
18
15
15
15
13
13
12
12
12
11
11
10
9
9
9
8
7
7
6
6
6
5
4
3
3
3
3
3
3
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
适用

430
247
199
2
2
宿主

381
73
5
4
3
克隆类型
多克隆
标记
This TRKA antibody is un-conjugated
17
15
15
12
10
10
9
9
9
9
8
7
7
7
7
7
6
3
2
2
2
2
1
应用范围
Immunofluorescence (IF)
264
148
93
88
67
59
55
43
19
10
5
5
4
4
3
1
选项
Supplier
Log in to see
Supplier Product No.
Log in to see
免疫原 The antiserum was produced against synthesized phosphopeptide derived from human TrkA around the phosphorylation site of tyrosine791 (P-V-Yp-L-D).
特异性 Antibody AP09480PU detects endogenous levels of TrkA only when phosphorylated at Tyrosine 791.
纯化方法 Immunoaffinity Chromatography using epitope-specific phosphopeptide.
别名 TrkA (NTRK1 Antibody 摘要)
背景 The Trk proto-oncogene family contains four members, TrkA, TrkB, TrkC, and TrkE, which are variably expressed throughout the central and peripheral nervous systems. TrkA binds to nerve growth factor (NGF) and autophosphorylates on tyrosine residues (Tyr490, Tyr674, Tyr675, Tyr751 and Tyr785) to activate multiple downstream effector proteins. Phosphorylation at Tyr490 is required for Shc association and subsequent activation of the Ras-MAP kinase-signaling cascade, which leads to activation of Elk-1-dependent gene transcription and neurite growth. Phosphorylations at Tyr674 and Tyr675 lie within the catalytic domain of TrkA tyrosine kinase and reflect Trk kinase activity. Additionally, phosphorylation at Tyr751 is required for PI3-kinase association and activation of the Akt signaling cascade.Synonyms: High affinity nerve growth factor receptor, NTRK1, Neurotrophic tyrosine kinase receptor type 1, TRK, TRK1-transforming tyrosine kinase protein, Trk-A, p140-TrkA
基因ID 4914
NCBI登录号 NP_001007793
UniProt P04629
研究领域 Cancer
途径 RTK signaling, Neurotrophin Signaling Pathway, cAMP Metabolic Process
应用备注 Immunofluorescence: 1/100approx. 1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
限制 仅限研究用
浓度 1.0 mg/mL
缓冲液 PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % Sodium Azide and 50 % Glycerol.
储存液 Sodium azide
注意事项 This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
注意事项 Avoid repeated freezing and thawing.
储存条件 -20 °C
储存方法 Store the antibody (in aliquots) at-20 °C.
厂商提供的图像
 image for anti-Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1) (pSer791) antibody (ABIN401580) anti-Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1) (pSer791) antibody
背景 Wiese, Jablonka, Holtmann, Orel, Rajagopal, Chao, Sendtner: "Adenosine receptor A2A-R contributes to motoneuron survival by transactivating the tyrosine kinase receptor TrkB." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, Issue 43, pp. 17210-5, 2007 (PubMed).

Valdez, Philippidou, Rosenbaum, Akmentin, Shao, Halegoua: "Trk-signaling endosomes are generated by Rac-dependent macroendocytosis." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, Issue 30, pp. 12270-5, 2007 (PubMed).

Inoue, Ito, Osato, Lee, Bae, Ito: "The transcription factor Runx3 represses the neurotrophin receptor TrkB during lineage commitment of dorsal root ganglion neurons." in: The Journal of biological chemistry, Vol. 282, Issue 33, pp. 24175-84, 2007 (PubMed).

您还需要查找其他产品吗?