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AHSA1 抗体 (Internal Region)

AHSA1 适用: 人, Chimpanzee WB, EIA 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN401377
发货至: 中国
  • 抗原 See all AHSA1 抗体
    AHSA1 (Activator of HSP90 ATPase Activity 1 (AHSA1))
    抗原表位
    • 10
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Internal Region
    适用
    • 61
    • 42
    • 16
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    人, Chimpanzee
    宿主
    • 44
    • 23
    • 17
    克隆类型
    • 45
    • 39
    多克隆
    标记
    • 35
    • 6
    • 5
    • 5
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This AHSA1 antibody is un-conjugated
    应用范围
    • 73
    • 63
    • 38
    • 38
    • 37
    • 35
    • 9
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), Enzyme Immunoassay (EIA)
    特异性
    This antibody is directed against AHA1 protein.
    交叉反应 (详细)
    Species reactivity (expected):Chimpanzee.
    Species reactivity (tested):Human.
    纯化方法
    Affinity chromatography
    免疫原
    Synthetic peptide corresponding to an internal region of human AHA1 protein
    亚型
    IgG
    Top Product
    Discover our top product AHSA1 Primary Antibody
  • 应用备注
    ELISA: 1/35,000 - 1/185,000. Western Blot: 1/500 - 1/3,000.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    限制
    仅限研究用
  • 浓度
    1.08 mg/mL (by UV absorbance at 280 nm)
    缓冲液
    0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 containing 0.01 % (w/v) Sodium Azide
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid repeated freezing and thawing.
    储存条件
    -20 °C
  • 抗原
    AHSA1 (Activator of HSP90 ATPase Activity 1 (AHSA1))
    别名
    AHA1 / AHSA1 (AHSA1 产品)
    别名
    ahsa1 antibody, MGC52884 antibody, MGC132147 antibody, MGC80312 antibody, AHSA1 antibody, MGC89589 antibody, wu:fb83b05 antibody, zgc:136821 antibody, zgc:56075 antibody, AHA1 antibody, C14orf3 antibody, p38 antibody, BC023857 antibody, AHA1, activator of heat shock 90kDa protein ATPase homolog 1 S homeolog antibody, activator of Hsp90 ATPase activity 1 antibody, AHA1, activator of heat shock 90kDa protein ATPase homolog 1 L homeolog antibody, activator of HSP90 ATPase activity 1 antibody, AHA1, activator of heat shock 90kDa protein ATPase homolog 1 antibody, AHA1, activator of heat shock protein ATPase homolog 1a antibody, AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast) antibody, AHA1, activator of heat shock protein ATPase 1 antibody, ahsa1.S antibody, AHSA1 antibody, ahsa1.L antibody, ahsa1 antibody, ahsa1a antibody, Ahsa1 antibody
    背景
    Activator of Hsp90 ATPase (AHA1) stimulates the inherent ATPase cycle of Hsp90, which is essential for its chaperone activity in vivo. The activation and/or stability of many of the key regulatory and signaling proteins of the eukaryotic cell depend on their interaction with the Hsp90 Molecular chaperone. Hsp90 is assisted and regulated by co-chaperones that participate in an ordered series both to assist clientprotein recruitment or release and to modulate progress through the ATPase coupled chaperone cycle. Structural analysis and mutagenesis show that binding of the N-terminal domain of AHA1 to Hsp90 promotes a conformational switch in the middle-segment catalytic loop (aa 370-390) of Hsp90 that exposes the catalytic Arg380 and enables its interaction with ATP in the N-terminal nucleotide-binding domain of the chaperone. Recent studies show that AHA1 modulates Hsp90-dependent stability of the folding of the cystic fibrosis transmembrane conductance regulator (CFTR) in the endoplasmic reticulum (ER). Down-regulation of AHA1 rescues misfolding of CFTR in cystic fibrosis.Synonyms: Activator of 90 kDa heat shock protein ATPase homolog 1, C14orf3, HSPC322
    基因ID
    10598
    NCBI登录号
    NP_036243
    UniProt
    O95433
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