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SMAD3 抗体 (Internal Region)

SMAD3 适用: 人, 小鼠, 大鼠 WB, EIA 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN401376
发货至: 中国
  • 抗原 See all SMAD3 抗体
    SMAD3 (SMAD, Mothers Against DPP Homolog 3 (SMAD3))
    抗原表位
    • 34
    • 29
    • 28
    • 28
    • 20
    • 14
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    • 11
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    Internal Region
    适用
    • 257
    • 150
    • 138
    • 28
    • 10
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    • 8
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    • 5
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    • 3
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    人, 小鼠, 大鼠
    宿主
    • 248
    • 23
    克隆类型
    • 231
    • 40
    多克隆
    标记
    • 138
    • 19
    • 14
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    This SMAD3 antibody is un-conjugated
    应用范围
    • 231
    • 117
    • 108
    • 74
    • 59
    • 55
    • 55
    • 53
    • 28
    • 13
    • 10
    • 8
    • 5
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    • 2
    • 1
    Western Blotting (WB), Enzyme Immunoassay (EIA)
    特异性
    This antibody is directed against Smad3 protein.
    交叉反应 (详细)
    Species reactivity (expected):Mouse, Rat.
    Species reactivity (tested):Human.
    纯化方法
    Affinity chromatography
    免疫原
    Synthetic peptide corresponding to an internal region of human Smad3 protein
    亚型
    IgG
    Top Product
    Discover our top product SMAD3 Primary Antibody
  • 应用备注
    ELISA: 1/15,000 - 1/50,000. Western Blot: 1/500 - 1/10,000.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    限制
    仅限研究用
  • 浓度
    1.06 mg/mL (by UV absorbance at 280 nm)
    缓冲液
    0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 containing 0.01 % (w/v) Sodium Azide
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid repeated freezing and thawing.
    储存条件
    -20 °C
  • 抗原
    SMAD3 (SMAD, Mothers Against DPP Homolog 3 (SMAD3))
    别名
    SMAD3 (SMAD3 产品)
    别名
    HSPC193 antibody, HsT17436 antibody, JV15-2 antibody, LDS1C antibody, LDS3 antibody, MADH3 antibody, madh3 antibody, madh3a antibody, smad3 antibody, wu:fa99e03 antibody, XSmad3 antibody, XenMLP antibody, Xmad3 antibody, madh3-A antibody, Madh3 antibody, AU022421 antibody, Smad 3 antibody, mad3 antibody, madh3b antibody, zgc:92234 antibody, SMAD family member 3 antibody, SMAD family member 3a antibody, SMAD family member 3 L homeolog antibody, SMAD family member 3b antibody, SMAD3 antibody, smad3a antibody, smad3.L antibody, Smad3 antibody, smad3b antibody
    背景
    Smad3 (also known as Mothers against decapentaplegic homolog 3, Mothers against DPP homolog 3, Mad3, hMAD-3, JV15-2 or hSMAD3) is a transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type I receptor kinase. These activators exert diverse effects on a wide array of cellular processes. The Smad proteins mediate much of the signaling responses induced by the TGF-beta superfamily. Briefly, activin type I receptor kinase phosphorylates receptor-activated Smads (R-Smads) at the two extreme serines in the C-terminal SSXS motif, e.g. Smad2 and Smad3 proteins in the TGF-beta pathway, or Smad1, Smad5 or Smad8 in the Bone Morphogenetic Proteins (BMP) pathway. The phosphorylated R-Smad then translocates into the nucleus, where it regulates transcription of target genes. Based on microarray and animal model experiments, Smad3 accounts for at least 80 % of all TGF-beta-mediated responses.Synonyms: JV15-2, MAD homolog 3, MAD-3, MADH3, Mad3, Mothers against DPP homolog 3, Mothers against decapentaplegic homolog 3, SMAD 3, SMAD family member 3, SMAD-3
    基因ID
    4088
    NCBI登录号
    NP_001138574
    UniProt
    P84022
    途径
    Cell Division Cycle, Chromatin Binding, Cell-Cell Junction Organization, Positive Regulation of Endopeptidase Activity, Autophagy
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