PRKG2 抗体 (C-Term)
(4 references)-
- 抗原 See all PRKG2 抗体
- PRKG2 (Protein Kinase, CGMP-Dependent, Type II (PRKG2))
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抗原表位
- AA 714-744, C-Term
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This PRKG2 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- 纯化方法
- This antibody is purified through a protein A column, followed by peptide affinity purification.
- 免疫原
- This cGKII antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 714-744 amino acids from the C-terminal region of human cGKII.
- 克隆位点
- RB01036
- 亚型
- Ig Fraction
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anti-Protein Kinase, CGMP-Dependent, Type II (PRKG2) (Internal Region) antibody
PRKG2 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Protein Kinase, CGMP-Dependent, Type II (PRKG2) (Ser363), (Thr359) antibodyPRKG2 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Protein Kinase, CGMP-Dependent, Type II (PRKG2) antibodyPRKG2 适用: 人 WB, IP, IF 宿主: 兔 Polyclonal unconjugated
anti-Protein Kinase, CGMP-Dependent, Type II (PRKG2) (AA 453-728) antibodyPRKG2 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Protein Kinase, CGMP-Dependent, Type II (PRKG2) (Ser126) antibodyPRKG2 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Protein Kinase, CGMP-Dependent, Type II (PRKG2) (N-Term) antibodyPRKG2 适用: 人, 小鼠, 大鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Protein Kinase, CGMP-Dependent, Type II (PRKG2) (AA 1-100) antibodyPRKG2 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Protein Kinase, CGMP-Dependent, Type II (PRKG2) (N-Term) antibodyPRKG2 适用: 人, 小鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Protein Kinase, CGMP-Dependent, Type II (PRKG2) (C-Term) antibodyPRKG2 适用: 人 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB: 1:1000. IHC-P: 1:50~100. IHC-P: 1:50~100
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
- 有效期
- 6 months
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: "Type II cGMP-dependent protein kinase directly inhibits HER2 activation of gastric cancer cells." in: Molecular medicine reports, Vol. 13, Issue 2, pp. 1909-13, (2016) (PubMed).
: "Nitric oxide/cyclic guanosine monophosphate inducers sodium nitroprusside and L-arginine inhibit the proliferation of gastric cancer cells via the activation of type II cyclic guanosine ..." in: Oncology letters, Vol. 10, Issue 1, pp. 479-484, (2015) (PubMed).
: "Type II cyclic guanosine monophosphate-dependent protein kinase inhibits epidermal growth factor receptor activation in different cancer cell lines." in: Oncology letters, Vol. 9, Issue 6, pp. 2781-2786, (2015) (PubMed).
: "Type II cGMP-dependent protein kinase mediates osteoblast mechanotransduction." in: The Journal of biological chemistry, Vol. 284, Issue 22, pp. 14796-808, (2009) (PubMed).
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: "Type II cGMP-dependent protein kinase directly inhibits HER2 activation of gastric cancer cells." in: Molecular medicine reports, Vol. 13, Issue 2, pp. 1909-13, (2016) (PubMed).
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- 抗原
- PRKG2 (Protein Kinase, CGMP-Dependent, Type II (PRKG2))
- 别名
- cGKII (PRKG2 产品)
- 别名
- MGC82580 antibody, PRKG2 antibody, si:dkey-18e17.2 antibody, PRKGR2 antibody, cGKII antibody, GDPKII antibody, AW212535 antibody, CGKII antibody, Prkgr2 antibody, cGK-II antibody, protein kinase, cGMP-dependent, type II antibody, protein kinase, cGMP-dependent, type II L homeolog antibody, cGMP-dependent protein kinase 2 antibody, PRKG2 antibody, prkg2.L antibody, prkg2 antibody, LOC100541294 antibody, Prkg2 antibody
- 背景
- CGKII is thought to play a key role in a diverse set of physiological pathway. cGKII may mediate intestinal secretion of water and electrolytes induced by the E. coli toxin STa and the intestinal peptide guanylin. Edentification of the pathway that mediates intestinal fluid secretion by E. coli STa has potential medical implications because STa causes traveler's diarrhea and about 50 % of infant mortality in developing countries. Transfection experiments in human cells disclose that cGKII phosphorylates SOX9 and attenuates SOX9 function by inhibiting its nuclear entry. Impaired differentiation of cultured KMI chondrocytes can be restored by silencing Sox9 by RNA interference. cGKII is postulated to be a molecular switch that couples the cessation of proliferation and the start of hypertrophic chondrocyte differentiation through attenuating SOX9 function.
- 分子量
- 87432
- 基因ID
- 5593
- NCBI登录号
- NP_006250
- UniProt
- Q13237
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