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ROR2 抗体 (N-Term)

ROR2 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB01507-01508 unconjugated
产品编号 ABIN392044
发货至: 中国
  • 抗原 See all ROR2 抗体
    ROR2 (Receptor Tyrosine Kinase-Like Orphan Receptor 2 (ROR2))
    抗原表位
    • 12
    • 9
    • 7
    • 7
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 19-50, N-Term
    适用
    • 74
    • 27
    • 25
    • 1
    • 1
    • 1
    • 1
    宿主
    • 68
    • 9
    克隆类型
    • 66
    • 11
    多克隆
    标记
    • 37
    • 6
    • 6
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    This ROR2 antibody is un-conjugated
    应用范围
    • 51
    • 35
    • 30
    • 15
    • 7
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    纯化方法
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    免疫原
    This ROR2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 19-50 amino acids from the N-terminal region of human ROR2.
    克隆位点
    RB01507-01508
    亚型
    Ig Fraction
    Top Product
    Discover our top product ROR2 Primary Antibody
  • 应用备注
    WB: 1:1000. IHC-P: 1:10~50. FC: 1:10~50
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    储存方法
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    有效期
    6 months
  • Wu, Xiong, Wang, Miao, Liu, Li, Zou, Liu, Zhao, Yang: "Comparative study of ROR2 and WNT5a expression in squamous/adenosquamous carcinoma and adenocarcinoma of the gallbladder." in: World journal of gastroenterology, Vol. 23, Issue 14, pp. 2601-2612, (2018) (PubMed).

    Ma, Henry, Llamosas, Higgins, Daniels, Hesson, Hawkins, Ward, Ford: "Validation of specificity of antibodies for immunohistochemistry: the case of ROR2." in: Virchows Archiv : an international journal of pathology, (2016) (PubMed).

    OConnell, Fiori, Xu, Carter, Frank, Camilli, French, Dissanayake, Indig, Bernier, Taub, Hewitt, Weeraratna: "The orphan tyrosine kinase receptor, ROR2, mediates Wnt5A signaling in metastatic melanoma." in: Oncogene, Vol. 29, Issue 1, pp. 34-44, (2010) (PubMed).

  • 抗原
    ROR2 (Receptor Tyrosine Kinase-Like Orphan Receptor 2 (ROR2))
    别名
    ROR2 (ROR2 产品)
    别名
    BDB antibody, BDB1 antibody, NTRKR2 antibody, Ntrkr2 antibody, mRor2 antibody, ROR2 antibody, bdb antibody, bdb1 antibody, Xror2 antibody, ntrkr2 antibody, MGC97773 antibody, LOC100219935 antibody, ror2 antibody, xror2 antibody, receptor tyrosine kinase like orphan receptor 2 antibody, receptor tyrosine kinase-like orphan receptor 2 antibody, receptor tyrosine kinase like orphan receptor 2 L homeolog antibody, ROR2 antibody, Ror2 antibody, ror2 antibody, ror2.L antibody
    背景
    ROR2 is a tyrosine-protein kinase receptor which may be involved in the early formation of the chondrocytes. It seems to be required for cartilage and growth plate development. This Type I membrane protein is expressed at high levels during early embryonic development. The expression levels drop strongly around day 16 and there are only very low levels in adult tissues. Defects in ROR2 are a cause of brachydactyly type B1 (BDB1). BDB1 is an autosomal dominant skeletal disorder characterized by hypoplasia/aplasia of distal phalanges and nails. In BDB1 the middle phalanges are short but in addition the terminal phalanges are rudimentary or absent. Both fingers and toes are affected. The thumbs and big toes are usually deformed. Defects in ROR2 are a cause of recessive Robinow syndrome (RRS). RRS is an autosomal disorder characterized by skeletal dysplasia with generalized limb bone shortening, segmental defects of the spine, brachydactyly and a dysmorphic facial appearance. The protein contains 1 frizzled (FZ) domain, 1 immunoglobulin-like C2-type domain, and 1 kringle domain.
    分子量
    104757
    基因ID
    4920
    NCBI登录号
    NP_004551
    UniProt
    Q01974
    途径
    RTK signaling, WNT signaling
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