Neutrophil Cytosolic Factor 4, 40kDa (NCF4) (AA 260-289), (C-Term) 抗体

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抗原
  • p40phox
  • AI451400
  • NCF
  • P40PHOX
  • SH3PXD4
  • p40phox protein
  • neutrophil cytosolic factor 4
  • neutrophil cytosolic factor 4, 40kDa
  • p40phox
  • LOC100136241
  • Ncf4
  • NCF4
抗原表位
AA 260-289, C-Term
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9
8
4
4
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3
3
3
2
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2
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2
1
1
1
1
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适用

117
58
44
7
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宿主

90
20
11
克隆类型 (克隆位点)
多克隆 ()
标记
非结合性
3
3
3
2
2
2
2
2
2
2
2
2
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2
1
1
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应用范围
Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
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41
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4
4
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3
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2
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选项
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免疫原 This NCF4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 260-289 AA from the C-terminal region of human NCF4.
克隆位点 RB18508
亚型 Ig
特异性 This NCF4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 267~297 amino acids from the C-terminal region of human NCF4.
纯化方法 This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
别名 NCF4 (NCF4 Antibody 摘要)
背景 NCF4 is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. This protein is preferentially expressed in cells of myeloid lineage. It interacts primarily with neutrophil cytosolic factor 2(NCF2/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1/p47-phox), which further interacts with the small G protein RAC1 and translocates to the membrane upon cell stimulation. This complex then activates flavocytochrome b, the membrane-integrated catalytic core of the enzyme system. The PX domain of this protein can bind phospholipid products of the PI(3) kinase, which suggests its role in PI(3) kinase-mediated signaling events. The phosphorylation of this protein was found to negatively regulate the enzyme activity.
Synonyms: Neutrophil cytosol factor 4, NCF-4, Neutrophil NADPH oxidase factor 4, p40-phox, p40phox, SH3 and PX domain-containing protein 4, SH3PXD4, NCF4
分子量 39032 DA
基因ID 4689
UniProt Q15080
研究领域 Cell Signaling, Cancer, Metabolism, Cell Structure
应用备注 WB = 1:1000, IHC (p) = 1:50-100, FACS = 1:10-50
限制 仅限研究用
状态 Liquid
浓度 2 mg/mL
缓冲液 PBS with 0.09 % (W/V) sodium azide
储存液 Sodium azide
注意事项 This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
储存条件 4 °C/-20 °C
储存方法 Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
有效期 6 months
厂商提供的图像
Western Blotting (WB) image for anti-Neutrophil Cytosolic Factor 4, 40kDa (NCF4) (AA 260-289), (C-Term) antibody (ABIN391905) Western blot analysis of NCF4 antibody (C-term) (ABIN391905) in K562 cell line lysate...
Immunohistochemistry (IHC) image for anti-Neutrophil Cytosolic Factor 4, 40kDa (NCF4) (AA 260-289), (C-Term) antibody (ABIN391905) Formalin-fixed and paraffin-embedded human lymphoma reacted with NCF4 Antibody (C-ter...
Flow Cytometry (FACS) image for anti-Neutrophil Cytosolic Factor 4, 40kDa (NCF4) (AA 260-289), (C-Term) antibody (ABIN391905) NCF4 Antibody (C-term) (ABIN391905) flow cytometry analysis of K562 cells (bottom his...
背景 Glas, Seiderer, Pasciuto, Tillack, Diegelmann, Pfennig, Konrad, Schmechel, Wetzke, Török, Stallhofer, Jürgens, Griga, Klein, Epplen, Schiemann, Mussack, Lohse, Göke, Ochsenkühn, Folwaczny, Müller-Myhsok, Brand: "rs224136 on chromosome 10q21.1 and variants in PHOX2B, NCF4, and FAM92B are not major genetic risk factors for susceptibility to Crohn's disease in the German population." in: The American journal of gastroenterology, Vol. 104, Issue 3, pp. 665-72, 2009 (PubMed).

Leto, Adams, de Mendez: "Assembly of the phagocyte NADPH oxidase: binding of Src homology 3 domains to proline-rich targets." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 91, Issue 22, pp. 10650-4, 1994 (PubMed).

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