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MARK1 抗体 (C-Term)

MARK1 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal RB8547 unconjugated
产品编号 ABIN391220
发货至: 中国
  • 抗原 See all MARK1 抗体
    MARK1 (MAP/microtubule Affinity-Regulating Kinase 1 (MARK1))
    抗原表位
    • 10
    • 8
    • 8
    • 7
    • 7
    • 7
    • 6
    • 2
    • 2
    • 1
    • 1
    AA 671-700, C-Term
    适用
    • 62
    • 35
    • 12
    • 5
    • 5
    • 2
    • 2
    • 2
    • 2
    • 1
    人, 小鼠
    宿主
    • 62
    • 1
    克隆类型
    • 63
    多克隆
    标记
    • 26
    • 7
    • 6
    • 6
    • 6
    • 6
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This MARK1 antibody is un-conjugated
    应用范围
    • 49
    • 44
    • 33
    • 11
    • 8
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB)
    纯化方法
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    免疫原
    This MARK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 671-700 amino acids from the C-terminal region of human MARK1.
    克隆位点
    RB8547
    亚型
    Ig Fraction
    Top Product
    Discover our top product MARK1 Primary Antibody
  • 应用备注
    WB: 1:1000
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    储存方法
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    有效期
    6 months
  • Hezel, Gurumurthy, Granot, Swisa, Chu, Bailey, Dor, Bardeesy, Depinho: "Pancreatic LKB1 deletion leads to acinar polarity defects and cystic neoplasms." in: Molecular and cellular biology, Vol. 28, Issue 7, pp. 2414-25, (2008) (PubMed).

  • 抗原
    MARK1 (MAP/microtubule Affinity-Regulating Kinase 1 (MARK1))
    别名
    MARK1 (MARK1 产品)
    别名
    MGC80341 antibody, MARK1 antibody, AW491150 antibody, B930025N23Rik antibody, Emk3 antibody, Par-1c antibody, mKIAA1477 antibody, mPar-1c antibody, MARK antibody, Par1c antibody, MAP/microtubule affinity-regulating kinase 1 S homeolog antibody, microtubule affinity regulating kinase 1 antibody, MAP/microtubule affinity-regulating kinase 1 antibody, MAP/microtubule affinity regulating kinase 1 antibody, mark1.S antibody, MARK1 antibody, mark1 antibody, Mark1 antibody
    背景
    MARK is a family of kinases that is known for its involvement in establishing cell polarity and in phosphorylating tau protein during Alzheimer neurodegeneration. Expression of MARK causes the phosphorylation of MAPs at their KXGS motifs, thereby detaching MAPs from the microtubules and thus facilitating the transport of particles. This occurs without impairing the intrinsic activity of motors because the velocity during active movement remains unchanged. In primary retinal ganglion cells, transfection with tau leads to the inhibition of axonal transport of mitochondria, APP vesicles, and other cell components which leads to starvation of axons and vulnerability against stress. This transport inhibition can be rescued by phosphorylating tau with MARK
    分子量
    89003
    基因ID
    4139
    NCBI登录号
    NP_061120
    UniProt
    Q9P0L2
    途径
    SARS-CoV-2 Protein Interactome, The Global Phosphorylation Landscape of SARS-CoV-2 Infection
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