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DCK 抗体 (C-Term)

DCK 适用: 人, 小鼠 WB, IF, IP, IHC (p) 宿主: 兔 Polyclonal RB05276 unconjugated
产品编号 ABIN391125
发货至: 中国
  • 抗原 See all DCK 抗体
    DCK (Deoxycytidine Kinase (DCK))
    抗原表位
    • 7
    • 6
    • 6
    • 5
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 171-200, C-Term
    适用
    • 51
    • 26
    • 14
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    人, 小鼠
    宿主
    • 43
    • 8
    • 3
    克隆类型
    • 48
    • 6
    多克隆
    标记
    • 31
    • 5
    • 5
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This DCK antibody is un-conjugated
    应用范围
    • 39
    • 25
    • 25
    • 24
    • 21
    • 10
    • 9
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    纯化方法
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    免疫原
    This DCK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 171-200 amino acids from the C-terminal region of human DCK.
    克隆位点
    RB05276
    亚型
    Ig Fraction
    Top Product
    Discover our top product DCK Primary Antibody
  • 应用备注
    IF: 1:10~50. IP: 1:500~1000. WB: 1:1000. IHC-P: 1:10~50
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    储存方法
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    有效期
    6 months
  • Hartford, Duan, Delaney, Mi, Kistner, Lamba, Huang, Dolan: "Population-specific genetic variants important in susceptibility to cytarabine arabinoside cytotoxicity." in: Blood, Vol. 113, Issue 10, pp. 2145-53, (2009) (PubMed).

    Lamba, Crews, Pounds, Schuetz, Gresham, Gandhi, Plunkett, Rubnitz, Ribeiro: "Pharmacogenetics of deoxycytidine kinase: identification and characterization of novel genetic variants." in: The Journal of pharmacology and experimental therapeutics, Vol. 323, Issue 3, pp. 935-45, (2007) (PubMed).

  • 抗原
    DCK (Deoxycytidine Kinase (DCK))
    别名
    DCK (DCK 产品)
    背景
    Deoxycytidine kinase is responsible for the phosphorylation of several deoxyribonucleosides and their analogs. Deficiency of this enzyme activity is associated with resistance to antiviral and anticancer chemotherapeutic agents, whereas increased enzyme activity is associated with increased activation of these compounds to cytotoxic nucleoside triphosphate derivatives. It is the rate limiting enzyme in the activation of many important anticancer and retroviral drugs and its activity is often decreased in cells that are resistant to cytosine arabinoside.
    分子量
    30519
    基因ID
    1633
    NCBI登录号
    NP_000779
    UniProt
    P27707
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