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SNCA 抗体 (C-Term)

SNCA 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal RB7377 unconjugated
产品编号 ABIN390368
发货至: 中国
  • 抗原 See all SNCA 抗体
    SNCA (Synuclein, alpha (SNCA))
    抗原表位
    • 73
    • 32
    • 27
    • 23
    • 15
    • 15
    • 13
    • 11
    • 11
    • 5
    • 4
    • 4
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    • 3
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    • 2
    • 2
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    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 104-133, C-Term
    适用
    • 305
    • 207
    • 206
    • 14
    • 10
    • 10
    • 9
    • 7
    • 7
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    人, 小鼠
    宿主
    • 246
    • 101
    • 6
    • 1
    • 1
    • 1
    克隆类型
    • 230
    • 127
    多克隆
    标记
    • 156
    • 25
    • 22
    • 17
    • 11
    • 9
    • 9
    • 9
    • 9
    • 9
    • 9
    • 8
    • 8
    • 7
    • 7
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    • 6
    • 6
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    This SNCA antibody is un-conjugated
    应用范围
    • 248
    • 171
    • 111
    • 82
    • 80
    • 74
    • 68
    • 54
    • 49
    • 49
    • 23
    • 21
    • 13
    • 9
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    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB)
    预测反应
    B, Pr, Pig
    纯化方法
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    免疫原
    This SNCA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 104-133 amino acids from the C-terminal region of human SNCA.
    克隆位点
    RB7377
    亚型
    Ig Fraction
    Top Product
    Discover our top product SNCA Primary Antibody
  • 应用备注
    WB: 1:1000. WB: 1:1000
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    储存方法
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    有效期
    6 months
  • 抗原
    SNCA (Synuclein, alpha (SNCA))
    别名
    alpha Synuclein (SNCA 产品)
    别名
    snca antibody, MGC64356 antibody, LOC619283 antibody, NACP antibody, alphaSYN antibody, PARK1 antibody, PARK4 antibody, PD1 antibody, synuclein alpha L homeolog antibody, alpha-synuclein antibody, synuclein alpha antibody, synuclein, alpha antibody, snca.L antibody, LOC619283 antibody, SNCA antibody, Snca antibody
    背景
    Alpha Synuclein is implicated in the regulation of dopamine release and transport. It is a soluble protein, expressed principally in the brain but also expressed in low concentrations in all tissues examined (except liver). In the nervous system, alpha Synuclein is primarily located at presynaptic terminals and is found membrane bound in dopaminergic neurons. It can form filamentous aggregates that are the major non amyloid component of intracellular inclusions in several neurodegenerative diseases (synucleinopathies), including Parkinson's Disease. Alpha Synuclein induces fibrillization of microtubule associated protein tau and reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase 3 activation. Alpha synuclein is a protein phosphorylated predominantly on serine residues. Two alternatively spliced transcripts of Alpha Synuclein have been identified. Additional splicing may be present but the full-length nature of these variants has not been determined. This variant (NACP140) is the longer transcript and encodes the longer isoform (NACP140). This antibody specific recognizing Alpha-synuclein isoform NACP140 not NACP112.
    分子量
    14460
    基因ID
    6622
    NCBI登录号
    NP_000336, NP_001139526, NP_001139527, NP_009292
    UniProt
    P37840
    途径
    Synaptic Membrane, Regulation of G-Protein Coupled Receptor Protein Signaling, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Platelet-derived growth Factor Receptor Signaling, Negative Regulation of Transporter Activity, Regulation of long-term Neuronal Synaptic Plasticity
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