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DDIT4 抗体 (N-Term)

DDIT4 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB12592 unconjugated
产品编号 ABIN390207
发货至: 中国
  • 抗原 See all DDIT4 抗体
    DDIT4 (DNA-Damage-Inducible Transcript 4 (DDIT4))
    抗原表位
    • 15
    • 14
    • 12
    • 8
    • 6
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    AA 20-49, N-Term
    适用
    • 53
    • 23
    • 9
    • 2
    • 2
    • 2
    • 2
    • 1
    宿主
    • 64
    • 4
    克隆类型
    • 66
    • 2
    多克隆
    标记
    • 27
    • 6
    • 5
    • 5
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    This DDIT4 antibody is un-conjugated
    应用范围
    • 45
    • 33
    • 26
    • 13
    • 13
    • 13
    • 7
    • 5
    • 3
    • 3
    • 3
    • 2
    • 2
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    纯化方法
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    免疫原
    This DDIT4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 20-49 amino acids from the N-terminal region of human DDIT4.
    克隆位点
    RB12592
    亚型
    Ig Fraction
  • 应用备注
    WB: 1:2000. IHC-P: 1:25. IHC-P: 1:25. IHC-P: 1:25
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    储存方法
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    有效期
    6 months
  • 抗原
    DDIT4 (DNA-Damage-Inducible Transcript 4 (DDIT4))
    别名
    DDIT4 (DDIT4 产品)
    别名
    redd1 antibody, Dig2 antibody, REDD-1 antibody, REDD1 antibody, 5830413E08Rik antibody, AA415483 antibody, Rtp801 antibody, dig2 antibody, rtp801 antibody, sb:cb821 antibody, zgc:64114 antibody, DNA damage inducible transcript 4 antibody, DNA-damage-inducible transcript 4 antibody, DNA damage inducible transcript 4 S homeolog antibody, ddit4 antibody, DDIT4 antibody, Ddit4 antibody, ddit4.S antibody
    背景
    REDD1 is a novel transcriptional target of p53 induced following DNA damage. During embryogenesis, REDD1 expression mirrors the tissue-specific pattern of the p53 family member p63, and TP63 null embryos show virtually no expression of REDD1, which is restored in mouse embryo fibroblasts following p63 expression. In differentiating primary keratinocytes, TP63 and REDD1 expression are coordinately downregulated, and ectopic expression of either gene inhibits in vitro differentiation. REDD1 appears to function in the regulation of reactive oxygen species (ROS), TP63 null fibroblasts have decreased ROS levels and reduced sensitivity to oxidative stress, which are both increased following ectopic expression of either TP63 or REDD1. Thus, REDD1 encodes a shared transcriptional target that implicates ROS in the p53-dependent DNA damage response and in p63-mediated regulation of epithelial differentiation.
    分子量
    25371
    基因ID
    54541
    NCBI登录号
    NP_061931
    UniProt
    Q9NX09
    途径
    Neurotrophin Signaling Pathway, Regulation of Carbohydrate Metabolic Process
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