TAP1 抗体 (C-Term)
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- 抗原 See all TAP1 抗体
- TAP1 (Transporter 1, ATP-Binding Cassette, Sub-Family B (MDR/TAP) (TAP1))
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抗原表位
- AA 765-794, C-Term
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This TAP1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- 纯化方法
- This antibody is purified through a protein A column, followed by peptide affinity purification.
- 免疫原
- This TAP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 765-794 amino acids from the C-terminal region of human TAP1.
- 克隆位点
- RB1815-1816
- 亚型
- Ig Fraction
- Top Product
- Discover our top product TAP1 Primary Antibody
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anti-Transporter 1, ATP-Binding Cassette, Sub-Family B (MDR/TAP) (TAP1) antibody
TAP1 适用: 人, 大鼠 WB, IP, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Transporter 1, ATP-Binding Cassette, Sub-Family B (MDR/TAP) (TAP1) (AA 524-808) antibodyTAP1 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Transporter 1, ATP-Binding Cassette, Sub-Family B (MDR/TAP) (TAP1) (AA 501-600) antibodyTAP1 适用: 人, Pig WB, ELISA, FACS, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Transporter 1, ATP-Binding Cassette, Sub-Family B (MDR/TAP) (TAP1) antibodyTAP1 适用: 人 WB, ELISA, IP, IF, ICC 宿主: 小鼠 Monoclonal 53H8 unconjugated
anti-Transporter 1, ATP-Binding Cassette, Sub-Family B (MDR/TAP) (TAP1) (AA 241-350) antibodyTAP1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1B11 unconjugated
anti-Transporter 1, ATP-Binding Cassette, Sub-Family B (MDR/TAP) (TAP1) (AA 241-350) antibodyTAP1 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 3D4 unconjugated
anti-Transporter 1, ATP-Binding Cassette, Sub-Family B (MDR/TAP) (TAP1) (AA 525-808) antibodyTAP1 适用: 人 WB, IHC, ICC 宿主: 兔 Polyclonal unconjugated
anti-Transporter 1, ATP-Binding Cassette, Sub-Family B (MDR/TAP) (TAP1) (Middle Region) antibodyTAP1 适用: 人, 小鼠, 大鼠, 兔, 斑马鱼, Cow, 豚鼠, 马 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Transporter 1, ATP-Binding Cassette, Sub-Family B (MDR/TAP) (TAP1) (AA 765-794) antibodyTAP1 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Transporter 1, ATP-Binding Cassette, Sub-Family B (MDR/TAP) (TAP1) (Internal Region) antibodyVerified TAP1 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
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- 应用备注
- WB: 1:1000. WB: 1:2000. IHC-P: 1:50~100
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
- 有效期
- 6 months
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- 抗原
- TAP1 (Transporter 1, ATP-Binding Cassette, Sub-Family B (MDR/TAP) (TAP1))
- 别名
- TAP1 (TAP1 产品)
- 别名
- ABC17 antibody, ABCB2 antibody, APT1 antibody, D6S114E antibody, PSF-1 antibody, PSF1 antibody, RING4 antibody, TAP1*0102N antibody, TAP1N antibody, abc17 antibody, abcb2 antibody, apt1 antibody, psf1 antibody, ring4 antibody, tap1a antibody, tap1n antibody, Abcb2 antibody, Ham-1 antibody, Ham1 antibody, MTP1 antibody, TAP antibody, Tap-1 antibody, Y3 antibody, Cim antibody, transporter 1, ATP binding cassette subfamily B member antibody, transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) L homeolog antibody, transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) antibody, TAP1 antibody, tap1.L antibody, Tap1 antibody
- 背景
- TAP is an integral transmembrane protein involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. It also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin. TAP is inhibited by the covalent attachment of herpes simplex virus ICP47 protein, which blocks the peptide-binding site of TAP. It is inhibited by human cytomegalovirus US6 glycoprotein, which binds to the lumenal side of the TAP complex and inhibits peptide translocation by specifically blocking ATP-binding to TAP and prevents the conformational rearrangement of TAP induced by peptide binding. TAP is also inhibited by human adenovirus E3-19K glycoprotein, which binds the TAP complex and acts as a tapasin inhibitor, preventing MHC class I/TAP association. Expression of TAP is down-regulated by human Epstein-barr virus vIL-10 protein, thereby affecting the transport of peptides into the endoplasmic reticulum and subsequent peptide loading by MHC class I molecules. TAP1 and TAP2 form a heterodimer of TAP1 and TAP2, and the peptide-binding site is shared between the cytoplasmic loops of TAP1 and TAP2. TAP, inducible by interferon gamma, belongs to the ABC transporter family, MDR subfamily.
- 分子量
- 87218
- 基因ID
- 6890
- NCBI登录号
- NP_000584
- UniProt
- Q03518
- 途径
- Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
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