LRP6 抗体 (C-Term)
(3 references)Our Local Distributor
北京 101111
Quick Overview for LRP6 抗体 (C-Term) (ABIN390100)
抗原
See all LRP6 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
-
-
抗原表位
- AA 1531-1560, C-Term
-
纯化方法
- This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
-
免疫原
- This LRP6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1531-1560 amino acids from the C-terminal region of human LRP6.
-
亚型
- Ig Fraction
-
-
anti-Low Density Lipoprotein Receptor-Related Protein 6 (LRP6) (AA 1198-1370) antibody
LRP6 适用: 人 ELISA, FACS 宿主: 小鼠 Monoclonal 1A3F5 unconjugated
anti-Low Density Lipoprotein Receptor-Related Protein 6 (LRP6) (AA 1546-1560) antibodyVerified LRP6 适用: 人 IHC, ELISA, FACS 宿主: 山羊 Polyclonal unconjugated
anti-Low Density Lipoprotein Receptor-Related Protein 6 (LRP6) (C-Term) antibodyLRP6 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Low Density Lipoprotein Receptor-Related Protein 6 (LRP6) (pSer1490) antibodyLRP6 适用: 人, 小鼠, 大鼠 WB, ELISA, IF (p), IF (cc), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Low Density Lipoprotein Receptor-Related Protein 6 (LRP6) (AA 981-1213) antibodyLRP6 适用: 人 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Low Density Lipoprotein Receptor-Related Protein 6 (LRP6) (AA 20-150) antibodyLRP6 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Low Density Lipoprotein Receptor-Related Protein 6 (LRP6) (AA 1531-1560) antibodyLRP6 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Low Density Lipoprotein Receptor-Related Protein 6 (LRP6) (AA 981-1213) antibodyLRP6 适用: 人 WB, IHC, ICC, IP 宿主: 小鼠 Monoclonal C3 unconjugated
anti-Low Density Lipoprotein Receptor-Related Protein 6 (LRP6) (C-Term) antibodyLRP6 适用: 人 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
- WB: 1:1000. IHC-P: 1:10~50
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- 4 °C,-20 °C
-
储存方法
- Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
-
有效期
- 6 months
-
-
-
: "LRP6 protein regulates low density lipoprotein (LDL) receptor-mediated LDL uptake." in: The Journal of biological chemistry, Vol. 287, Issue 2, pp. 1335-44, (2012) (PubMed).
: "Wild-type LRP6 inhibits, whereas atherosclerosis-linked LRP6R611C increases PDGF-dependent vascular smooth muscle cell proliferation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 108, Issue 5, pp. 1914-8, (2011) (PubMed).
: "LRP6 overexpression defines a class of breast cancer subtype and is a target for therapy." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 11, pp. 5136-41, (2010) (PubMed).
-
-
- LRP6 (Low Density Lipoprotein Receptor-Related Protein 6 (LRP6))
-
别名
- LRP6
-
背景
- LRP6 is essential for the Wnt/beta catenin signaling pathway, probably by acting as a coreceptor together with Frizzled for Wnt. It is a specific, high-affinity receptor for DKK1 and DKK2, but not DKK3. The interaction with DKK1 blocks LRP6-mediated Wnt/beta catenin signaling via LRP6 removal via Kremen proteins-mediated endocytosis.
-
分子量
- 180429
-
基因ID
- 4040
-
NCBI登录号
- NP_002327
-
UniProt
- O75581
-
途径
- WNT signaling, Tube Formation
抗原
-
