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CRY2 抗体 (C-Term)

CRY2 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB1846 unconjugated
产品编号 ABIN390080
发货至: 中国
  • 抗原 See all CRY2 抗体
    CRY2 (Cryptochrome 2 (Photolyase-Like) (CRY2))
    抗原表位
    • 10
    • 6
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 564-593, C-Term
    适用
    • 36
    • 15
    • 5
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    人, 小鼠
    宿主
    • 32
    • 6
    克隆类型
    • 34
    • 4
    多克隆
    标记
    • 21
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This CRY2 antibody is un-conjugated
    应用范围
    • 31
    • 16
    • 15
    • 7
    • 4
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    纯化方法
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    免疫原
    This Cry2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 564-593 amino acids from the C-terminal region of human Cry2.
    克隆位点
    RB1846
    亚型
    Ig Fraction
    Top Product
    Discover our top product CRY2 Primary Antibody
  • 应用备注
    WB: 1:1000. WB: 1:1000. WB: 1:1000. IHC-P: 1:50~100
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid freeze-thaw cycles.
    储存条件
    4 °C,-20 °C
    储存方法
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots.
    有效期
    6 months
  • Wang, Wang, Liu, Liu, Tay, Walsh, Yang, Wu: "CRISPR/Cas9 mediated genome editing of Helicoverpa armigera with mutations of an ABC transporter gene HaABCA2 confers resistance to Bacillus thuringiensis Cry2A toxins." in: Insect biochemistry and molecular biology, Vol. 87, pp. 147-153, (2017) (PubMed).

  • 抗原
    CRY2 (Cryptochrome 2 (Photolyase-Like) (CRY2))
    别名
    Cry2 (CRY2 产品)
    背景
    Various biochemical, physiological and behavioural processes display circadian rhythms controlled by an internal biological clock. The central ?gears?driving this clock appear to be composed of an autoregulatory transcription/posttranslation-based feedback loop. Cryptochrome 1 (CRY1) and 2 (CRY2) are DNA-binding flavoproteins that bear some homology to blue-light receptors and photolyases. In Drosophila, CRY is a photoreceptor for the circadian clock where it binds to the clock component TIM in a light-dependent fashion and blocks its function. Mammalian CRY1 and CRY2 function via light-independent interactions with circadian genes CLOCK and BMAL1, as well as with PER1, PER2, and TIM. They seem to act as light-independent components of the circadian clock and likely regulate Per1 transcriptional cycling via interactions with both the activator and its feedback inhibitors. Mutant mice not expressing the Cry1 or Cry2 protein display accelerated and delayed periodicity of locomotor activity, respectively. It appears that the combination of both proteins working together is essential to synchronize the organism to circadian phases. A critical balance between Cry1 and Cry2 is required for proper clock function, in complete darkness, double-mutant mice present with instantaneous arrhythmicity, indicating the absence of an internal circadian clock.
    分子量
    66947
    基因ID
    1408
    NCBI登录号
    NP_001120929, NP_066940
    UniProt
    Q49AN0
    途径
    Response to Water Deprivation, Protein targeting to Nucleus
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