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ABCB11 抗体 (C-Term)

ABCB11 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB2211 unconjugated
产品编号 ABIN390059
发货至: 中国
  • 抗原 See all ABCB11 抗体
    ABCB11 (ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 11 (ABCB11))
    抗原表位
    • 7
    • 6
    • 4
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1038-1067, C-Term
    适用
    • 28
    • 15
    • 6
    人, 小鼠
    宿主
    • 29
    • 4
    克隆类型
    • 29
    • 4
    多克隆
    标记
    • 19
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This ABCB11 antibody is un-conjugated
    应用范围
    • 19
    • 13
    • 11
    • 7
    • 5
    • 5
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    纯化方法
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    免疫原
    This ABCB11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1038-1067 amino acids from the C-terminal region of human ABCB11.
    克隆位点
    RB2211
    亚型
    Ig Fraction
    Top Product
    Discover our top product ABCB11 Primary Antibody
  • 应用备注
    WB: 1:1000. IHC-P: 1:50~100
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid freeze-thaw cycles.
    储存条件
    4 °C,-20 °C
    储存方法
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots.
    有效期
    6 months
  • Bochkis, Rubins, White, Furth, Friedman, Kaestner: "Hepatocyte-specific ablation of Foxa2 alters bile acid homeostasis and results in endoplasmic reticulum stress." in: Nature medicine, Vol. 14, Issue 8, pp. 828-36, (2008) (PubMed).

    Truog: ""Do-not-resuscitate" orders during anesthesia and surgery." in: Anesthesiology, Vol. 74, Issue 3, pp. 606-8, (1991) (PubMed).

  • 抗原
    ABCB11 (ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 11 (ABCB11))
    别名
    ABCB11 (ABCB11 产品)
    别名
    ABCB11 antibody, Bsep antibody, ABC16 antibody, BRIC2 antibody, BSEP antibody, PFIC-2 antibody, PFIC2 antibody, PGY4 antibody, SPGP antibody, Lith1 antibody, BSEP/SPGP antibody, Spgp antibody, ATP binding cassette subfamily B member 11 antibody, bile salt export pump antibody, ATP-binding cassette, sub-family B (MDR/TAP), member 11 antibody, ABCB11 antibody, LOC100489744 antibody, LOC100565276 antibody, EDI_111220 antibody, EDI_272930 antibody, abcb11 antibody, Abcb11 antibody
    背景
    ABCB11 is involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes. It is expressed predominatly, if not exclusively, in the liver, where it is further localized to the canilicular microvilli and to subcanilicular vesicles fo the hepatocytes. Structurally, ABCB11 is a multifunctional polypeptide with two homologus halves, each containing a hydrophobic membrane-anchoring domain and an ATP binding cassette (ABC) domain. Defects in ABCB11 are the cause of progressive familial intrahepatic cholestasis 2 (PFIC2). PFIC2 is an inherited liver disease of childhood which is characterized by cholestasis and normal serum gamma-glutamyltransferase activity. Defects in ABCB11 are also found in cases of chronic intrahepatic cholestasis without obvious familial history of chronic liver disease.
    分子量
    146407
    基因ID
    8647
    NCBI登录号
    NP_003733
    UniProt
    O95342
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