(2 references)-
- 抗原 See all NFkB 抗体
- NFkB (Nuclear Factor kappa B (NFkB))
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抗原表位
- pSer536
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适用
- 人, 小鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This NFkB antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 纯化方法
- This antibody is purified through a protein A column, followed by peptide affinity purification.
- 免疫原
- This NFKB Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S536 of human NFKB.
- 克隆位点
- RB5212
- 亚型
- Ig Fraction
- Top Product
- Discover our top product NFkB Primary Antibody
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anti-Nuclear Factor kappa B (NFkB) (AA 805-892) antibody
NFkB 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Nuclear Factor kappa B (NFkB) (AA 42-367) antibodyNFkB 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Nuclear Factor kappa B (NFkB) (AA 352-439) antibodyNFkB 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Nuclear Factor kappa B (NFkB) antibodyNFkB 适用: 人 CP unconjugated
anti-Nuclear Factor kappa B (NFkB) (AA 40-365) antibodyNFkB 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Nuclear Factor kappa B (NFkB) (AA 47-372) antibodyNFkB 适用: 小鸡 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Nuclear Factor kappa B (NFkB) (pSer536) antibodyNFkB 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Nuclear Factor kappa B (NFkB) (pSer536) antibodyNFkB 适用: 人 DB 宿主: 兔 Polyclonal RB22552 unconjugated
anti-Nuclear Factor kappa B (NFkB) (pSer536) antibodyNFkB 适用: 人 DB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB: 1:500
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
- 有效期
- 6 months
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: "miR-221/222 promote cancer stem-like cell properties and tumor growth of breast cancer via targeting PTEN and sustained Akt/NF-κB/COX-2 activation." in: Chemico-biological interactions, Vol. 277, pp. 33-42, (2017) (PubMed).
: "Activation of NF-{kappa}B by TMPRSS2/ERG Fusion Isoforms through Toll-Like Receptor-4." in: Cancer research, Vol. 71, Issue 4, pp. 1325-33, (2011) (PubMed).
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: "miR-221/222 promote cancer stem-like cell properties and tumor growth of breast cancer via targeting PTEN and sustained Akt/NF-κB/COX-2 activation." in: Chemico-biological interactions, Vol. 277, pp. 33-42, (2017) (PubMed).
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- 抗原
- NFkB (Nuclear Factor kappa B (NFkB))
- 别名
- NFKB (NFkB 产品)
- 别名
- EBP-1 antibody, KBF1 antibody, NF-kB1 antibody, NF-kappa-B antibody, NF-kappaB antibody, NFKB-p105 antibody, NFKB-p50 antibody, NFkappaB antibody, p105 antibody, p50 antibody, NF-kB antibody, NF-KB1 antibody, NF-kappaB1 antibody, p50/p105 antibody, nuclear factor kappa B subunit 1 antibody, nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 antibody, NFKB1 antibody, Nfkb1 antibody
- 背景
- NFKB1 or NFKB2 is bound to REL, RELA, or RELB to form the NFKB complex. The p50 (NFKB1)/p65 (RELA) heterodimer is the most abundant form of NFKB. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA or NFKBIB), which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA or IKBKB) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NFKB complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T, R is an A or G purine, and Y is a C or T pyrimidine).
- 分子量
- 60219
- 基因ID
- 5970
- NCBI登录号
- NP_001138610, NP_001230913, NP_068810
- UniProt
- Q04206
- 途径
- Ubiquitin Proteasome Pathway, S100 Proteins
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