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ABL1 抗体 (pTyr134)

ABL1 适用: 人 IHC (p), DB 宿主: 兔 Polyclonal RB7343 unconjugated
产品编号 ABIN389501
发货至: 中国
  • 抗原 See all ABL1 抗体
    ABL1 (C-Abl Oncogene 1, Non-Receptor tyrosine Kinase (ABL1))
    抗原表位
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    pTyr134
    适用
    • 255
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    宿主
    • 339
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    克隆类型
    • 339
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    多克隆
    标记
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    This ABL1 antibody is un-conjugated
    应用范围
    • 224
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    Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Dot Blot (DB)
    预测反应
    Zf, M
    纯化方法
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    免疫原
    This ABL1 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y134 of human ABL1.
    克隆位点
    RB7343
    亚型
    Ig Fraction
    Top Product
    Discover our top product ABL1 Primary Antibody
  • 应用备注
    IHC-P: 1:50~100. DB: 1:500
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    储存方法
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    有效期
    6 months
  • Asmussen, Lasater, Tajon, Oses-Prieto, Jun, Taylor, Burlingame, Craik, Shah: "MEK-dependent negative feedback underlies BCR-ABL-mediated oncogene addiction." in: Cancer discovery, Vol. 4, Issue 2, pp. 200-15, (2014) (PubMed).

  • 抗原
    ABL1 (C-Abl Oncogene 1, Non-Receptor tyrosine Kinase (ABL1))
    别名
    ABL1 (ABL1 产品)
    别名
    ABL antibody, JTK7 antibody, bcr/abl antibody, c-ABL antibody, p150 antibody, v-abl antibody, AI325092 antibody, Abl antibody, E430008G22Rik antibody, c-Abl antibody, ABL proto-oncogene 1, non-receptor tyrosine kinase antibody, c-abl oncogene 1, non-receptor tyrosine kinase antibody, Tyrosine-protein kinase abl-1 antibody, ABL1 antibody, Abl1 antibody, abl-1 antibody, abl1 antibody
    背景
    ABL1 is a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. The t(9,22) translocation results in the head-to-tail fusion of the BCR and ABL1 genes present in many cases of chronic myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1.
    分子量
    122873
    基因ID
    25
    NCBI登录号
    NP_005148, NP_009297
    UniProt
    P00519
    途径
    Apoptosis, Regulation of Muscle Cell Differentiation, Platelet-derived growth Factor Receptor Signaling, Lipid Metabolism
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