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LGR5 抗体 (AA 689-719)

LGR5 适用: 人, 小鼠, 大鼠 WB, FACS 宿主: 兔 Polyclonal RB14211 unconjugated
产品编号 ABIN389218
发货至: 中国
  • 抗原 See all LGR5 抗体
    LGR5 (Leucine-Rich Repeat Containing G Protein-Coupled Receptor 5 (LGR5))
    抗原表位
    • 16
    • 15
    • 8
    • 7
    • 7
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 689-719
    适用
    • 101
    • 56
    • 48
    • 1
    • 1
    人, 小鼠, 大鼠
    宿主
    • 89
    • 13
    克隆类型
    • 78
    • 24
    多克隆
    标记
    • 48
    • 6
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This LGR5 antibody is un-conjugated
    应用范围
    • 75
    • 38
    • 22
    • 20
    • 17
    • 17
    • 14
    • 13
    • 9
    • 7
    • 3
    • 1
    • 1
    • 1
    Western Blotting (WB), Flow Cytometry (FACS)
    纯化方法
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    免疫原
    This LGR5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 689-719 amino acids from human LGR5.
    克隆位点
    RB14211
    亚型
    IgG
    Top Product
    Discover our top product LGR5 Primary Antibody
  • 应用备注
    WB: 1:1000. IF: 1:100. FC: 1:25
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid freeze-thaw cycles.
    储存条件
    4 °C,-20 °C
    储存方法
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots.
    有效期
    6 months
  • Huch, Gehart, van Boxtel, Hamer, Blokzijl, Verstegen, Ellis, van Wenum, Fuchs, de Ligt, van de Wetering, Sasaki, Boers, Kemperman, de Jonge, Ijzermans, Nieuwenhuis, Hoekstra, Strom, Vries et al.: "Long-term culture of genome-stable bipotent stem cells from adult human liver. ..." in: Cell, Vol. 160, Issue 1-2, pp. 299-312, (2015) (PubMed).

    Ying, Tsujii, Kondo, Hayashi, Kato, Akasaka, Inoue, Shiraishi, Inoue, Hiyama, Tsujii, Maekawa, Kawai, Fujinaga, Araki, Shinzaki, Watabe, Nishida, Iijima, Takehara: "The effectiveness of an anti-human IL-6 receptor monoclonal antibody combined with chemotherapy to target colon cancer stem-like cells." in: International journal of oncology, Vol. 46, Issue 4, pp. 1551-9, (2015) (PubMed).

    Singh, Mallela, Cornuet, Reifler, Chervenak, West, Wong, Nasonkin: "Characterization of Three-Dimensional Retinal Tissue Derived from Human Embryonic Stem Cells in Adherent Monolayer Cultures." in: Stem cells and development, Vol. 24, Issue 23, pp. 2778-95, (2015) (PubMed).

    Jardé, Kass, Staples, Lescesen, Carne, Oliva, McMurrick, Abud: "ERBB3 Positively Correlates with Intestinal Stem Cell Markers but Marks a Distinct Non Proliferative Cell Population in Colorectal Cancer." in: PLoS ONE, Vol. 10, Issue 9, pp. e0138336, (2015) (PubMed).

    Bu, Zheng, Zhang, Li, Sun, Dong, Wu, Wu, Wang, Cheng, Xing, Li, Du, Ji: "LGR5 is a promising biomarker for patients with stage I and II gastric cancer." in: Chinese journal of cancer research = Chung-kuo yen cheng yen chiu, Vol. 25, Issue 1, pp. 79-89, (2013) (PubMed).

    Zheng, Sun, Bu, Zhang, Li, Wu, Wu, Wang, Cheng, Xing, Du, Ji: "Intestinal stem cell marker LGR5 expression during gastric carcinogenesis." in: World journal of gastroenterology : WJG, Vol. 19, Issue 46, pp. 8714-21, (2013) (PubMed).

    Maddox, Shakya, South, Shelton, Andersen, Chidester, Kang, Gligorich, Jones, Spangrude, Welm, Tantin: "Transcription factor Oct1 is a somatic and cancer stem cell determinant." in: PLoS genetics, Vol. 8, Issue 11, pp. e1003048, (2012) (PubMed).

    Judah, Rudkouskaya, Wilson, Carter, Dagnino: "Multiple roles of integrin-linked kinase in epidermal development, maturation and pigmentation revealed by molecular profiling." in: PLoS ONE, Vol. 7, Issue 5, pp. e36704, (2012) (PubMed).

    Takahashi, Ishii, Nishida, Takemasa, Mizushima, Ikeda, Yokobori, Mimori, Yamamoto, Sekimoto, Doki, Mori: "Significance of Lgr5(+ve) cancer stem cells in the colon and rectum." in: Annals of surgical oncology, Vol. 18, Issue 4, pp. 1166-74, (2011) (PubMed).

    Satoh, Obayashi, Tabunoki, Wakana, Kim: "Stable expression of neurogenin 1 induces LGR5, a novel stem cell marker, in an immortalized human neural stem cell line HB1.F3." in: Cellular and molecular neurobiology, Vol. 30, Issue 3, pp. 415-26, (2010) (PubMed).

  • 抗原
    LGR5 (Leucine-Rich Repeat Containing G Protein-Coupled Receptor 5 (LGR5))
    别名
    LGR5/GPR49 (LGR5 产品)
    别名
    lgr5-a antibody, lgr5a antibody, FEX antibody, Gpr49 antibody, GPR49 antibody, GPR67 antibody, GRP49 antibody, HG38 antibody, leucine-rich repeat containing G protein-coupled receptor 5 L homeolog antibody, leucine rich repeat containing G protein coupled receptor 5 antibody, leucine rich repeat containing G protein-coupled receptor 5 antibody, lgr5.L antibody, Lgr5 antibody, LGR5 antibody
    背景
    LGR5/GPR49 is an orphan receptor. It may be an important receptor for signals controlling growth and differentiation of specific embryonic tissues. Stem cell marker of the intestinal epithelium and the hair follicle. Target gene of Wnt signaling. Expressed in skeletal muscle, placenta, spinal cord, and various region of brain. Expressed at the base of crypts in colonic and small mucosa stem cells. In premalignant cancer expression is not restricted to the cript base. Overexpressed in cancers of the ovary, colon and liver.
    分子量
    99998
    基因ID
    8549
    NCBI登录号
    NP_001264155, NP_003658
    UniProt
    O75473
    途径
    WNT signaling
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