EPS15 抗体 (C-Term)
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北京 101111
Quick Overview for EPS15 抗体 (C-Term) (ABIN388933)
抗原
See all EPS15 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 840-870, C-Term
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预测反应
- M
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纯化方法
- This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
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免疫原
- This EPS15 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 840-870 amino acids from the C-terminal region of human EPS15.
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亚型
- Ig Fraction
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anti-Epidermal Growth Factor Receptor Pathway Substrate 15 (EPS15) (AA 660-840) antibody
EPS15 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Epidermal Growth Factor Receptor Pathway Substrate 15 (EPS15) (AA 575-625) antibodyEPS15 适用: 人 IF (p), IHC 宿主: 兔 Polyclonal unconjugated
anti-Epidermal Growth Factor Receptor Pathway Substrate 15 (EPS15) antibodyEPS15 适用: 人, 小鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Epidermal Growth Factor Receptor Pathway Substrate 15 (EPS15) (pTyr849) antibodyEPS15 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Epidermal Growth Factor Receptor Pathway Substrate 15 (EPS15) (C-Term) antibodyEPS15 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Epidermal Growth Factor Receptor Pathway Substrate 15 (EPS15) (AA 794-843) antibodyEPS15 适用: 人, 小鼠, 大鼠, Cow, 马, Pig, 豚鼠, 猴, 兔, Bat WB 宿主: 兔 Polyclonal unconjugated
anti-Epidermal Growth Factor Receptor Pathway Substrate 15 (EPS15) (pTyr849) antibodyEPS15 适用: 人, 小鼠, 大鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Epidermal Growth Factor Receptor Pathway Substrate 15 (EPS15) (pTyr849) antibodyEPS15 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Epidermal Growth Factor Receptor Pathway Substrate 15 (EPS15) (AA 575-625) antibodyEPS15 适用: 人 WB, IP, IHC (fp) 宿主: 兔 Polyclonal unconjugated
anti-Epidermal Growth Factor Receptor Pathway Substrate 15 (EPS15) (AA 2-88) antibodyEPS15 适用: 人, 小鼠, 大鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB: 1:1000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
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有效期
- 6 months
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- EPS15 (Epidermal Growth Factor Receptor Pathway Substrate 15 (EPS15))
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别名
- EPS15
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背景
- EPS15 is involved in cell growth regulation, possibly via the regulation of mitogenic signals and control of cell proliferation. EPS15 also participates in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Potential interaction partners include AP2A2, STN2, EPN1, and CRK via its SH3-binding sites. EPS15 is ubiquitously expressed. Phosphorylation on Tyr-849 is involved in the internalization of EGFR. EPS15 is not required for membrane translocation after EGF treatment or for targeting to coated pits, but essential for a subsequent step in EGFR endocytosis. This protein is involved in a t(1,11)(p32,q23) chromosomal translocation in acute leukemias causing fusion to the trithorax (MLL or HRX) gene product which contains DNA-binding motifs resulting in a rogue activator protein. Structurally, EPS15 contains 2 EF-hand calcium-binding domains, 3 EH domains, and 2 ubiquitin-interacting motif (UIM) repeats.
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分子量
- 98656
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基因ID
- 2060
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NCBI登录号
- NP_001153441, NP_001972
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UniProt
- P42566
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途径
- EGFR Signaling Pathway, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, EGFR Downregulation
抗原
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