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UVRAG 抗体 (C-Term)

UVRAG 适用: 人, 小鼠 WB, IF, IHC (p) 宿主: 兔 Polyclonal RB10849 unconjugated
产品编号 ABIN388586
发货至: 中国
  • 抗原 See all UVRAG 抗体
    UVRAG (UV Radiation Resistance Associated Gene (UVRAG))
    抗原表位
    • 14
    • 9
    • 6
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 666-699, C-Term
    适用
    • 63
    • 37
    • 30
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    人, 小鼠
    宿主
    • 59
    • 4
    克隆类型
    • 61
    • 2
    多克隆
    标记
    • 26
    • 5
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This UVRAG antibody is un-conjugated
    应用范围
    • 56
    • 21
    • 13
    • 12
    • 11
    • 11
    • 9
    • 9
    • 6
    • 2
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    纯化方法
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    免疫原
    This UVRAG antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 666-699 amino acids from the C-terminal region of human UVRAG.
    克隆位点
    RB10849
    亚型
    Ig Fraction
    Top Product
    Discover our top product UVRAG Primary Antibody
  • 应用备注
    IF: 1:10~50. IF: 1:200. WB: 1:1000. IHC-P: 1:50~100
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    储存方法
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    有效期
    6 months
  • Armstrong, Corazzari, Martin, Pagliarini, Falasca, Hill, Ellis, Al Sabah, Redfern, Fimia, Piacentini, Lovat: "Oncogenic B-RAF signaling in melanoma impairs the therapeutic advantage of autophagy inhibition." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 17, Issue 8, pp. 2216-26, (2011) (PubMed).

    Sun, Zhang, Fan, Wong, Ding, Chen, Zhong: "The RUN domain of rubicon is important for hVps34 binding, lipid kinase inhibition, and autophagy suppression." in: The Journal of biological chemistry, Vol. 286, Issue 1, pp. 185-91, (2011) (PubMed).

    Neely, Green, LaFerla: "Presenilin is necessary for efficient proteolysis through the autophagy-lysosome system in a ?-secretase-independent manner." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 31, Issue 8, pp. 2781-91, (2011) (PubMed).

    Sun, Westphal, Wong, Tan, Zhong: "Rubicon controls endosome maturation as a Rab7 effector." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 45, pp. 19338-43, (2010) (PubMed).

    Gao, Kang, Liao, Ding, Gambotto, Watkins, Liu, Stolz, Yin: "Biochemical isolation and characterization of the tubulovesicular LC3-positive autophagosomal compartment." in: The Journal of biological chemistry, Vol. 285, Issue 2, pp. 1371-83, (2010) (PubMed).

    Sun, Fan, Chen, Ding, Chen, Zhong: "Identification of Barkor as a mammalian autophagy-specific factor for Beclin 1 and class III phosphatidylinositol 3-kinase." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 49, pp. 19211-6, (2008) (PubMed).

    Han, Hou, Goldstein, Lu, Stolz, Yin, Rabinowich: "Involvement of protective autophagy in TRAIL resistance of apoptosis-defective tumor cells." in: The Journal of biological chemistry, Vol. 283, Issue 28, pp. 19665-77, (2008) (PubMed).

  • 抗原
    UVRAG (UV Radiation Resistance Associated Gene (UVRAG))
    别名
    UVRAG (UVRAG 产品)
    别名
    DHTX antibody, VPS38 antibody, p63 antibody, 9530039D02Rik antibody, AI648770 antibody, BB124205 antibody, Uvrag1 antibody, Uvragl antibody, zgc:56164 antibody, uvrag antibody, MGC81810 antibody, UVRAG antibody, MGC131135 antibody, CG6116 antibody, Dmel\\CG6116 antibody, UV radiation resistance associated antibody, UV radiation resistance associated gene antibody, UV radiation resistance associated S homeolog antibody, UV radiation resistance associated L homeolog antibody, UV-resistance associated gene antibody, UVRAG antibody, Uvrag antibody, uvrag antibody, uvrag.S antibody, uvrag.L antibody
    背景
    UVRAG complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells and encodes a protein with a C2 domain. The protein activates the Beclin1-PI(3)KC3 complex, promoting autophagy and suppressing the proliferation and tumorigenicity of human colon cancer cells. Chromosomal aberrations involving this gene are associated with left-right axis malformation and mutations in this gene have been associated with colon cancer.
    分子量
    78151
    基因ID
    7405
    NCBI登录号
    NP_003360
    UniProt
    Q9P2Y5
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