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BIM 抗体 (AA 130-165)

BCL2L11 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB00963 unconjugated
产品编号 ABIN388101
发货至: 中国
  • 抗原 See all BIM (BCL2L11) 抗体
    BIM (BCL2L11) (BCL2-Like 11 (Apoptosis Facilitator) (BCL2L11))
    抗原表位
    • 16
    • 15
    • 15
    • 7
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    • 7
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    AA 130-165
    适用
    • 178
    • 101
    • 91
    • 5
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    宿主
    • 166
    • 9
    • 5
    • 1
    克隆类型
    • 151
    • 30
    多克隆
    标记
    • 68
    • 16
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    This BIM antibody is un-conjugated
    应用范围
    • 123
    • 65
    • 51
    • 28
    • 25
    • 21
    • 15
    • 14
    • 14
    • 13
    • 10
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    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    纯化方法
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    免疫原
    This Bim BH3 Domain antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 130-165 amino acids from human Bim BH3 Domain.
    克隆位点
    RB00963
    亚型
    Ig Fraction
    Top Product
    Discover our top product BCL2L11 Primary Antibody
  • 应用备注
    WB: 1:1000. IHC-P: 1:50~100
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    储存方法
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    有效期
    6 months
  • Jiao, Li, Zhang, Liu, Chi: "Role of Sirtuin3 in high glucose-induced apoptosis in renal tubular epithelial cells." in: Biochemical and biophysical research communications, Vol. 480, Issue 3, pp. 387-393, (2017) (PubMed).

    Del Gaizo Moore, Schlis, Sallan, Armstrong, Letai: "BCL-2 dependence and ABT-737 sensitivity in acute lymphoblastic leukemia." in: Blood, Vol. 111, Issue 4, pp. 2300-9, (2008) (PubMed).

  • 抗原
    BIM (BCL2L11) (BCL2-Like 11 (Apoptosis Facilitator) (BCL2L11))
    别名
    Bim (BCL2L11 产品)
    别名
    bim antibody, BAM antibody, BIM antibody, BOD antibody, 1500006F24Rik antibody, Bim antibody, Bod antibody, BimL antibody, BIMEL antibody, BCL2-like 11 antibody, BCL2 like 11 antibody, BCL2-like 11 (apoptosis facilitator) antibody, bcl2l11 antibody, BCL2L11 antibody, Bcl2l11 antibody
    背景
    Bim belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. Bim contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family, including BCL2, BCL2L1/BCL-X(L), and MCL1, and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection.
    分子量
    22171
    基因ID
    10018
    NCBI登录号
    NP_001191035, NP_001191036, NP_001191037, NP_001191038, NP_001191039, NP_001191040, NP_001191041, NP_001191042, NP_006529, NP_619527, NP_619528, NP_619529, NP_619530, NP_619531, NP_61953
    UniProt
    O43521
    途径
    PI3K-Akt Signaling, Neurotrophin Signaling Pathway, Tube Formation, Positive Regulation of Endopeptidase Activity
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