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LSD1 抗体 (C-Term)

Name: LSD1 抗体 (C-Term)
SKU: ABIN388023
Availability: OutOfStock

KDM1A 适用: 人 WB, IF, IHC (p) 宿主: 兔 Polyclonal RB7583 unconjugated

Western blot analysis of AOF2 (arrow) using LSD1 Antibody (C-term) (ABIN388023 and ABIN2845465).

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining.

IHC (p)

Fluorescent confocal image of Hela cell stained with hLSD1- (ABIN388023 and ABIN2845465).

4 images

(2 references)

产品编号 ABIN388023

发货至: 中国

Datasheet as PDF

抗原 See all LSD1 (KDM1A) 抗体

LSD1 (KDM1A) (Lysine (K)-Specific Demethylase 1A (KDM1A))
抗原表位
15

8

7

5

4

3

3

3

2

2

2

1

1

1

1

1

1

1

1

1

1
AA 819-852, C-Term
适用
76

37

29

6

3

2

1

1

1

1

1

1

1
人
宿主
59

16

1

1
兔
Compatible Secondaries
克隆类型
61

17
多克隆
标记
58

3

3

3

1

1

1

1

1

1

1

1

1

1

1
This LSD1 antibody is un-conjugated
应用范围
70

36

25

21

18

13

13

12

6

5

4

4

3

2

2

1

1
Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

预测反应

M

纯化方法

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

免疫原

This LSD1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 819-852 amino acids from the C-terminal region of human LSD1.

克隆位点

RB7583

亚型

Ig Fraction

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anti-Lysine (K)-Specific Demethylase 1A (KDM1A) (AA 709-876) antibody
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anti-Lysine (K)-Specific Demethylase 1A (KDM1A) (AA 55-263) antibody
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anti-Lysine (K)-Specific Demethylase 1A (KDM1A) (AA 55-263) antibody
KDM1A 适用: 人, 猴 WB, ELISA, IHC, FACS, ICC 宿主: 小鼠 Monoclonal 3F9A3 unconjugated

anti-Lysine (K)-Specific Demethylase 1A (KDM1A) (AA 753-851) antibody
KDM1A 适用: 人 WB, ELISA, IF, IHC (p) 宿主: 小鼠 Monoclonal 2E7 unconjugated

anti-Lysine (K)-Specific Demethylase 1A (KDM1A) (AA 108-142) antibody
KDM1A 适用: 人, 小鼠 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Lysine (K)-Specific Demethylase 1A (KDM1A) (AA 819-852) antibody
KDM1A 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Lysine (K)-Specific Demethylase 1A (KDM1A) (AA 100-150) antibody
KDM1A 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Lysine (K)-Specific Demethylase 1A (KDM1A) antibody
KDM1A 适用: 人 WB, ELISA, IHC 宿主: 兔 Monoclonal 1G7 unconjugated Recombinant Antibody

应用备注

IF: 1:10~50. WB: 1:1000. WB: 1:1000. IHC-P: 1:50~100

限制

仅限研究用
状态

Liquid

缓冲液

Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C,-20 °C

储存方法

Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

有效期

6 months
Huang, Li, Song, Li, Li, Zhang, Han, Zhang, Miao, Du, Wang: "Lysine-specific demethylase 1 (LSD1/KDM1A) contributes to colorectal tumorigenesis via activation of the Wnt/?-catenin pathway by down-regulating Dickkopf-1 (DKK1) [corrected]." in: PLoS ONE, Vol. 8, Issue 7, pp. e70077, (2013) (PubMed).

Nishikawa, Toyota, Suzuki, Honma, Fujikane, Ohmura, Nishidate, Ohe-Toyota, Maruyama, Sonoda, Sasaki, Urano, Imai, Hirata, Tokino: "Gene amplification and overexpression of PRDM14 in breast cancers." in: Cancer research, Vol. 67, Issue 20, pp. 9649-57, (2007) (PubMed).
抗原

LSD1 (KDM1A) (Lysine (K)-Specific Demethylase 1A (KDM1A))

别名

LSD1 (KDM1A 产品)

别名

AOF2 antibody, BHC110 antibody, KDM1 antibody, LSD1 antibody, 1810043O07Rik antibody, AA408884 antibody, Aof2 antibody, D4Ertd478e antibody, Kdm1 antibody, Lsd1 antibody, mKIAA0601 antibody, DKFZp459N2450 antibody, RGD1562975 antibody, aof2 antibody, kdm1 antibody, wu:fb82e06 antibody, wu:fc51a02 antibody, wu:fj36a05 antibody, wu:fj66b06 antibody, KDM1A antibody, lsd1 antibody, xLSD1 antibody, AtLSD1 antibody, F9F13.30 antibody, F9F13_30 antibody, LESION SIMULATING DISEASE antibody, LESION SIMULATING DISEASE 1 antibody, lysine demethylase 1A antibody, lysine (K)-specific demethylase 1A antibody, lysine (K)-specific demethylase 1a antibody, LSD1 zinc finger family protein antibody, KDM1A antibody, Kdm1a antibody, kdm1a antibody, LSD1 antibody

背景

LSD1 is a histone demethylase that specifically demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. LSD1 contains a SWIRM domain, a FAD-binding motif, and an amine oxidase domain. This protein is a component of several histone deacetylase complexes, though it silences genes by functioning as a histone demethylase. It acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. LSD1 demethylates both mono- and tri-methylted 'Lys-4' of histone H3. This protein may play a role in the repression of neuronal genes. Alone, it is unable to demethylate H3 'Lys-4' on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity. It may also demethylate 'Lys-9' of histone H3, a specific tag for epigenetic transcriptional repression, thereby leading to derepression of androgen receptor target genes.

分子量

92903

基因ID

23028

NCBI登录号

NP_001009999, NP_055828

UniProt

O60341

途径

Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, Negative Regulation of intrinsic apoptotic Signaling, Warburg Effect