IRAK3 抗体 (C-Term, Internal Region)
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- 抗原 See all IRAK3 抗体
- IRAK3 (Interleukin-1 Receptor-Associated Kinase 3 (IRAK3))
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抗原表位
- C-Term, Internal Region
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适用
- 小鼠, 大鼠
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宿主
- 山羊
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克隆类型
- 多克隆
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标记
- This IRAK3 antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 特异性
- This antibody recognizes IRAK3 (C-term).
- 交叉反应 （详细）
- Species reactivity (tested):Mouse, Rat.
- 纯化方法
- Affinity chromatography
- 免疫原
- Peptide with sequence C-GHSYGSKPMEKR, from the internal region (near the CTerminus) of the protein sequence
- Top Product
- Discover our top product IRAK3 Primary Antibody
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anti-Interleukin-1 Receptor-Associated Kinase 3 (IRAK3) (AA 454-596) antibody
IRAK3 适用: 人 WB, ELISA, IHC, ICC, FACS 宿主: 小鼠 Monoclonal 6G9G2 unconjugated
anti-Interleukin-1 Receptor-Associated Kinase 3 (IRAK3) (AA 1-596) antibodyIRAK3 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1C9 unconjugated
anti-Interleukin-1 Receptor-Associated Kinase 3 (IRAK3) (AA 497-596) antibodyIRAK3 适用: 人 WB, ELISA, RNAi 宿主: 小鼠 Monoclonal 1F6 unconjugated
anti-Interleukin-1 Receptor-Associated Kinase 3 (IRAK3) (Internal Region) antibodyVerified IRAK3 适用: 小鼠, 大鼠 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Interleukin-1 Receptor-Associated Kinase 3 (IRAK3) antibodyIRAK3 适用: 人 WB, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Interleukin-1 Receptor-Associated Kinase 3 (IRAK3) (AA 1-596) antibodyIRAK3 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Interleukin-1 Receptor-Associated Kinase 3 (IRAK3) (AA 497-596) antibodyIRAK3 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 1F1 unconjugated
anti-Interleukin-1 Receptor-Associated Kinase 3 (IRAK3) (C-Term) antibodyIRAK3 适用: 人 WB, IHC, IF, IC 宿主: 兔 Polyclonal unconjugated
anti-Interleukin-1 Receptor-Associated Kinase 3 (IRAK3) (AA 491-540) antibodyIRAK3 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Interleukin-1 Receptor-Associated Kinase 3 (IRAK3) (AA 367-596) antibodyIRAK3 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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Peptide ELISA: 1/64000. Western Blot: 0.05 - 0.2 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - 限制
- 仅限研究用
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- 浓度
- 0,5 mg/mL
- 缓冲液
- Tris saline, pH ~7.3, 0.02 % Sodium Azide, 0.5 % BSA
- 储存液
- Sodium azide
- 注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freezing and thawing.
- 储存条件
- 4 °C/-20 °C
- 储存方法
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- 抗原
- IRAK3 (Interleukin-1 Receptor-Associated Kinase 3 (IRAK3))
- 别名
- IRAK3 (IRAK3 产品)
- 别名
- IRAK3 antibody, si:dkey-150i15.2 antibody, ASRT5 antibody, IRAKM antibody, IrakM antibody, 4833428C18Rik antibody, AI563835 antibody, IRAK-M antibody, interleukin 1 receptor associated kinase 3 antibody, interleukin-1 receptor-associated kinase 3 antibody, IRAK3 antibody, irak3 antibody, Irak3 antibody
- 背景
- Reduced expression of IRAK-1 and increased expression of IRAK-M after CpG DNA pretreatment resulted in the hyporesponsiveness of macrophages that leads to the protection of mice from hepatic injury and death caused by CpG DNA/D-GalN. Endotoxin tolerance was significantly reduced in macrophages from IRAK-M knockout mice. IRAK-M regulates TLR signaling and innate immune homeostasis. induction of IRAK-M and inhibition of kinase activity of IRAK-1 are crucial to PGN-induced tolerance in macrophages. IRAK-M is a key regulator of the bone loss that is due to osteoclastic resorption of bone. IRAK-M induction negatively regulates Toll-like receptor-dependent interleukin-12 p40 production in macrophages in the presence of Mycobacterium tuberculosis lipoarabinomannan. These findings indicate that IRAK-M selectively attenuates p38 activation and inhibits innate immunity through stabilizing MKP-1. IRAK-M is directly involved in the regulation of both innate and adaptive immune signaling processes, and deletion of IRAK-M enhances host anti-tumor immune response.Synonyms: IL-1 receptor-associated kinase M, IRAK-3, IRAK-M, Interleukin-1 receptor-associated kinase 3
- 基因ID
- 11213
- NCBI登录号
- NP_001135995
- UniProt
- Q9Y616
- 途径
- TLR signaling, Activation of Innate immune Response, Production of Molecular Mediator of Immune Response, Toll-Like Receptors Cascades
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