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ACVR1 抗体 (Internal Region)

ACRV1 适用: 人, 小鼠, 大鼠, 犬 WB 宿主: 山羊 Polyclonal unconjugated
产品编号 ABIN374913
发货至: 中国
  • 抗原 See all ACVR1 (ACRV1) 抗体
    ACVR1 (ACRV1) (Activin Receptor Type I (ACRV1))
    抗原表位
    • 22
    • 20
    • 10
    • 7
    • 7
    • 7
    • 6
    • 6
    • 6
    • 6
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Internal Region
    适用
    • 87
    • 42
    • 16
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    人, 小鼠, 大鼠, 犬
    宿主
    • 83
    • 5
    • 3
    • 3
    山羊
    克隆类型
    • 91
    • 3
    多克隆
    标记
    • 49
    • 15
    • 6
    • 6
    • 6
    • 6
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This ACVR1 antibody is un-conjugated
    应用范围
    • 85
    • 57
    • 45
    • 14
    • 5
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    Western Blotting (WB)
    特异性
    This antibody reacts to ACVR1.
    交叉反应 (详细)
    Species reactivity (expected):Mouse, Rat, Canine.
    Species reactivity (tested):Human.
    纯化方法
    Affinity chromatography
    免疫原
    Peptide with sequence C-RKFKRRNQERLNPRD, from the internal region of the protein sequence
    Top Product
    Discover our top product ACRV1 Primary Antibody
  • 应用备注
    Peptide ELISA: 1/128000. Western Blot: 0.3 - 1 μg/mL. Immunohistochemistry on paraffin sections: 4 - 6 μg/mL.
    限制
    仅限研究用
  • 浓度
    0,5 mg/mL
    缓冲液
    Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid repeated freezing and thawing.
    储存条件
    4 °C/-20 °C
    储存方法
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • 抗原
    ACVR1 (ACRV1) (Activin Receptor Type I (ACRV1))
    Abstract
    ACRV1 产品
    别名
    ACTRI antibody, ACVR1A antibody, ACVRLK2 antibody, ALK2 antibody, FOP antibody, SKR1 antibody, TSRI antibody, ActR-IA antibody, ActR-I antibody, ActRIA antibody, Acvr antibody, Acvrlk2 antibody, Alk-2 antibody, Alk8 antibody, D330013D15Rik antibody, Tsk7L antibody, actri antibody, acvr1 antibody, acvr1-a antibody, acvr1-b antibody, acvr1a antibody, acvrlk2 antibody, alk-2 antibody, alk2 antibody, alk8 antibody, fop antibody, sax antibody, skr1 antibody, tsri antibody, xALK-2 antibody, activin A receptor type 1 antibody, activin A receptor, type 1 antibody, activin A receptor type 1 S homeolog antibody, ACVR1 antibody, Acvr1 antibody, acvr1.S antibody
    背景
    Activin Receptor Type IA on ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Activin receptor IA is highly conserved and is a receptor for BMP2 and BMP4. Activin type I receptors transduce signals for a variety of members of the Transforming growth factor beta superfamily of ligands. This family of cytokines and hormones inlude activin, Anti-müllerian hormone (AMH), bone morphogenetic proteins (BMPs), and Nodal. They are involved in a host of physiological processes including, growth, cell differentiation, homeostasis, osteogenesis, apoptosis and many other functions. There are three type I Activin receptors:ACVR1, ACVR1B, and ACVR1C Each bind to a specific type II receptor-ligand complex. Despite the large amount of processes that these ligands regulate, they all operate through essentially the same pathway: A ligand binds to a Type two receptor, which recruits and trans-phosphorylate a type I receptor. The type I receptor recruits a receptor regulated SMAD (R-SMAD) which it phosphorylates. The RSMAD then translocates to the nucleus where it functions as a transcription factor.Synonyms: ACRV1A, ACVRLK2, ALK2, Activin receptor type IA, Activin receptor-like kinase 2, SKR1, Serine/threonine-protein kinase receptor R1, TGF-B superfamily receptor type I
    基因ID
    90, 9606
    UniProt
    Q04771
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