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APBA1 抗体 (Internal Region)

APBA1 适用: 人, 小鼠, 大鼠 WB 宿主: 山羊 Polyclonal unconjugated
产品编号 ABIN374796
发货至: 中国
  • 抗原 See all APBA1 抗体
    APBA1 (Amyloid beta (A4) Precursor Protein-Binding, Family A, Member 1 (APBA1))
    抗原表位
    • 15
    • 5
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Internal Region
    适用
    人, 小鼠, 大鼠
    宿主
    • 25
    • 1
    山羊
    克隆类型
    • 26
    多克隆
    标记
    • 12
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This APBA1 antibody is un-conjugated
    应用范围
    • 24
    • 13
    • 13
    • 8
    • 5
    • 4
    • 4
    • 3
    • 3
    • 1
    • 1
    Western Blotting (WB)
    序列
    C-EASHPSQDGK RQYK
    特异性
    This antibody detects APBA1 / MINT1.
    交叉反应 (详细)
    Species reactivity (expected):Mouse, Rat.
    Species reactivity (tested):Human.
    纯化方法
    Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide
    免疫原
    Peptide from the internal region of the protein sequence according to NP_001154.2. Genename: APBA1
    Top Product
    Discover our top product APBA1 Primary Antibody
  • 应用备注
    Peptide ELISA: Detection Limit: 1/16000. Western blot: 0.1-0.3 μg/mL. Approx 100 kDa band observed in Human Brain (Cerebellumand Hippocampus) lysates (calculated MW of 92.0 kDa according to NP_001154.2).
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    限制
    仅限研究用
  • 浓度
    0.5 mg/mL
    缓冲液
    Tris saline, pH 7.3 containing 0.02 % Sodium Azide as preservative and 0.5 % BSA as stabilizer
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid repeated freezing and thawing.
    储存条件
    4 °C/-20 °C
    储存方法
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • 抗原
    APBA1 (Amyloid beta (A4) Precursor Protein-Binding, Family A, Member 1 (APBA1))
    别名
    APBA1 / MINT1 (APBA1 产品)
    别名
    APBA1 antibody, 6430513E09Rik antibody, Lin-10 antibody, Mint antibody, Mint1 antibody, Urop11 antibody, X11 antibody, X11alpha antibody, D9S411E antibody, LIN10 antibody, MINT1 antibody, X11A antibody, X11ALPHA antibody, amyloid beta precursor protein binding family A member 1 antibody, amyloid beta (A4) precursor protein-binding, family A, member 1b antibody, ketopantoate reductase antibody, 2-dehydropantoate 2-reductase antibody, amyloid beta (A4) precursor protein-binding, family A, member 1 (X11) antibody, amyloid beta (A4) precursor protein-binding, family A, member 1 antibody, amyloid beta (A4) precursor protein binding, family A, member 1 antibody, APBA1 antibody, apba1b antibody, apbA1 antibody, apba1 antibody, Apba1 antibody
    背景
    APBA1 is part of two multimeric complexes, the first containing Munc18-1 and syntaxin 1 and the second being a brain specific heterotrimeric complex with LIN-10/X11-alpha, LIN-2/CASK, and LIN7. It binds to the cytoplasmic domain of amyloid protein (APP). ABPA1 has a putative function in synaptic vesicle exocytosis by binding to Munc18-1, an essential component of the synaptic vesicle exocytotic machinery. It may modulate processing of the beta amyloid precursor protein (APP) and hence formation of beta APP. The munc-18 interacting (Mint) protein family is a group of evolutionarily conserved adaptor proteins that function in membrane transport and organization. In mammals, there exist three Mint isoforms, Mint 1, 2, and 3. Although there is little amino acid sequence conservation in the amino-terminal half, the carboxy-terminal half of these proteins is highly conserved. Within this conserved portion there exists a phosphotyrosine-binding (PTB) and a PSD-95/DLG-A/ZO-1 (PDZ) domain, which function as protein interaction modules. Mint 1 and 2 appear to be expressed exclusively in the brain and are found to bind to Munc18, an essential component of the synaptic vesicle fusion machinery. Mint 3 is ubiquitously expressed in all tissues and is expressed at the lowest levels in the brain and testis. Studies show that Mint3 does not interact with munc-18. Mint 3 has been found to interact with the Alzheimer's Disease-related amyloid precursor protein (APP) and does so through its PTB and PDZ domains. It has been suggested that Mint3 links APP to other transport machinery components, thereby regulating it transport, endocytosis, and metabolism. Abnormal APP metabolism has been shown to be the cause of an early-onset type of Alzheimer's disease.Synonyms: Adapter protein X11alpha, Amyloid beta A4 precursor protein-binding family A member 1, Neuron-specific X11 protein, Neuronal Munc18-1-interacting protein 1
    基因ID
    320, 9606
    UniProt
    Q02410
    途径
    Synaptic Vesicle Exocytosis, Dicarboxylic Acid Transport
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