电话:
400-7060-959
传真:
+86 10 56315212-8813
电子邮件:
orders@antibodies-online.cn

Complement Factor H 抗体 (Internal Region)

CFH 适用: 人 WB 宿主: 山羊 Polyclonal unconjugated
产品编号 ABIN374588
发货至: 中国
  • 抗原 See all Complement Factor H (CFH) 抗体
    Complement Factor H (CFH)
    抗原表位
    • 15
    • 9
    • 5
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Internal Region
    适用
    • 68
    • 25
    • 22
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    宿主
    • 59
    • 16
    • 4
    • 1
    山羊
    克隆类型
    • 55
    • 25
    多克隆
    标记
    • 39
    • 9
    • 8
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This Complement Factor H antibody is un-conjugated
    应用范围
    • 64
    • 25
    • 16
    • 15
    • 13
    • 13
    • 12
    • 11
    • 8
    • 6
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB)
    特异性
    This antibody is expected to recognize isoform a of Complement factor H (CFH) only.
    纯化方法
    Affinity chromatography
    免疫原
    Peptide with sequence C-HLVPDRKKDQYK, from the internal region of the protein sequence
    Top Product
    Discover our top product CFH Primary Antibody
  • 应用备注
    Peptide ELISA: 1/32000. Western Blot: 0.03 - 0.1 μg/mL.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    限制
    仅限研究用
  • 浓度
    0,5 mg/mL
    缓冲液
    Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid repeated freezing and thawing.
    储存条件
    4 °C/-20 °C
    储存方法
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • 抗原
    Complement Factor H (CFH)
    Abstract
    CFH 产品
    别名
    AHUS1 antibody, AMBP1 antibody, ARMD4 antibody, ARMS1 antibody, CFHL3 antibody, FH antibody, FHL1 antibody, HF antibody, HF1 antibody, HF2 antibody, HUS antibody, Mud-1 antibody, NOM antibody, Sas-1 antibody, Sas1 antibody, Fh antibody, CFH antibody, im:7147412 antibody, si:ch211-207o17.2 antibody, fH antibody, armd4 antibody, arms1 antibody, cfh antibody, cfhl3 antibody, fhl1 antibody, hf1 antibody, hf2 antibody, hus antibody, complement factor H antibody, complement component factor h antibody, complement factor H-related protein 5 antibody, complement factor H L homeolog antibody, CFH antibody, Cfh antibody, cfh antibody, LOC100399888 antibody, LOC100733902 antibody, cfh.L antibody
    背景
    The complement Factor H protein is secreted into the bloodstream and acts in the regulation of complement activation. Mutations leading to changes in this protein have been linked with HUS (hemolytic-uremic syndrome) and chronic hypocomplementemic nephropathy. Factor H is mainly synthesised in the liver but also in macrophages and endothelium. It is primarily aplasma glycoprotein but is also found in platelets and there is a membrane bound form on some leukocytes. Consisting of a single polypeptide, the major form of Factor H has a molecular weight of 155 kDa. There are two truncated forms, a non-glycosylated 49 kDa form and a glycosylated 39-43 kDaform. Plasma concentrations are in the range 200-600 mg/L for the 155 kDa form and 1-5 mg/L for thetruncated forms. Factor H is a major regulatory protein of the complement system. By binding to C3b it either displacesor prevents the binding of Bb (activated Factor B). When bound to Factor H, C3b is susceptible tocleavage by Factor 1 to yield iC3b. Factor H is released or modified following this cleavage. The regulatory role of Factor H is essential because C3bBb is not only a C5 convertase but a C3 convertaseand so has a positive feedback effect, potentially consuming the entire C3 pool if unregulated.Synonyms: CFH, H factor 1, HF, HF1, HF2
    基因ID
    3075
    NCBI登录号
    NP_000177
    UniProt
    P08603
    途径
    Complement System, Cellular Response to Molecule of Bacterial Origin
You are here:
客服