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DKK2 抗体 (C-Term)

DKK2 适用: 人, 小鼠, 大鼠, 犬, Cow WB 宿主: 山羊 Polyclonal unconjugated
产品编号 ABIN374181
发货至: 中国
  • 抗原 See all DKK2 抗体
    DKK2 (Dickkopf 2 Homolog (DKK2))
    抗原表位
    • 10
    • 8
    • 8
    • 8
    • 6
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    适用
    • 60
    • 15
    • 4
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    人, 小鼠, 大鼠, 犬, Cow
    宿主
    • 56
    • 3
    • 1
    山羊
    克隆类型
    • 57
    • 3
    多克隆
    标记
    • 28
    • 9
    • 6
    • 4
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This DKK2 antibody is un-conjugated
    应用范围
    • 48
    • 33
    • 31
    • 9
    • 3
    • 2
    • 2
    • 2
    • 1
    Western Blotting (WB)
    特异性
    This antibody detects Dickkopf-2 at C-term.
    交叉反应 (详细)
    Species reactivity (expected):Mouse, Rat, Canine, Bovine.
    Species reactivity (tested):Human.
    纯化方法
    Affinity chromatography
    免疫原
    Peptide with sequence ATYSSKARLHVCQKI, from the C Terminus of the protein sequence Genename: DKK2
    Top Product
    Discover our top product DKK2 Primary Antibody
  • 应用备注
    Peptide ELISA: 1/8000. Western blot: 1 - 3 μg/mL. Approx 28 kDa band observed in Human Heart lysate (calculatedMW of 28.8 kDa according to NP_055236).
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    限制
    仅限研究用
  • 浓度
    0.5 mg/mL
    缓冲液
    Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid repeated freezing and thawing.
    储存条件
    4 °C/-20 °C
    储存方法
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • 抗原
    DKK2 (Dickkopf 2 Homolog (DKK2))
    别名
    Dickkopf-2 (DKK2) (DKK2 产品)
    别名
    DKK-2 antibody, Dkk4 antibody, zgc:171574 antibody, dickkopf WNT signaling pathway inhibitor 2 antibody, DKK2 antibody, Dkk2 antibody, dkk2 antibody
    背景
    Analysis of individual DKK domains and chimeric DKKs shows that the carboxy-terminal domains of both DKK1 and DKK2 associate with LRP6 and are necessary and sufficient for Wnt8 inhibition. Xenopus Dickkopf 1 (DKK1) was initially discovered as a Wnt antagonist that plays an important role in head formation. By far, four members of DKK have been identified in mammals. Each DKK molecule contains two conserved cysteine-rich domains. Recent studies showed that the second Cys-rich domains of DKK1 and DKK2 inhibited Wnt3a-activated signaling, whereas the first Cys-rich domains had no effects. In addition, the second Cys-rich domain of DKK2, but not that of DKK1, was able to activate the canonical pathway in the presence of LRP6, and this LRP-dependent signaling does not require Dvl.Synonyms: Dickkopf-related protein 2, Dkk-2
    基因ID
    27123
    NCBI登录号
    NP_055236
    UniProt
    Q9UBU2
    途径
    WNT signaling
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