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ALS2 抗体 (C-Term)

ALS2 适用: 人, 小鼠, 大鼠, Cow, 犬 IHC (p) 宿主: 山羊 Polyclonal unconjugated
产品编号 ABIN374168
发货至: 中国
  • 抗原 See all ALS2 抗体
    ALS2 (Amyotrophic Lateral Sclerosis 2 (Juvenile) (ALS2))
    抗原表位
    • 15
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    适用
    • 38
    • 12
    • 6
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    人, 小鼠, 大鼠, Cow, 犬
    宿主
    • 35
    • 4
    • 1
    山羊
    克隆类型
    • 36
    • 3
    多克隆
    标记
    • 26
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This ALS2 antibody is un-conjugated
    应用范围
    • 22
    • 14
    • 13
    • 13
    • 7
    • 5
    • 4
    • 3
    • 1
    • 1
    • 1
    Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    序列
    LKACYYQIQR EKLN
    特异性
    This antibody detects Alsin / ALS2 at C-term.
    纯化方法
    Ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide
    免疫原
    Peptide from C Terminus of the protein sequence according to NP_065970.2 Genename: ALS2
    Top Product
    Discover our top product ALS2 Primary Antibody
  • 应用备注
    Peptide ELISA: Limit dilution 1: 8000. Immunohistochemistry: 3-5 μg/mL. In paraffin embedded Human Cortex shows pixulatecytoplasm staining in some neuronal cells.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    限制
    仅限研究用
  • 浓度
    0.5 mg/mL
    缓冲液
    Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid repeated freezing and thawing.
    储存条件
    4 °C/-20 °C
    储存方法
    Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C.
  • 抗原
    ALS2 (Amyotrophic Lateral Sclerosis 2 (Juvenile) (ALS2))
    别名
    Alsin / ALS2 (ALS2 产品)
    别名
    als2 antibody, si:dkey-33m14.1 antibody, ALS2CR6 antibody, ALSJ antibody, IAHSP antibody, PLSJ antibody, 3222402C23Rik antibody, 9430073A21Rik antibody, Als2cr6 antibody, Alsin antibody, mKIAA1563 antibody, amyotrophic lateral sclerosis 2a (juvenile) antibody, alsin antibody, ALS2, alsin Rho guanine nucleotide exchange factor antibody, amyotrophic lateral sclerosis 2 (juvenile) antibody, als2a antibody, CpipJ_CPIJ008258 antibody, CpipJ_CPIJ008260 antibody, ALS2 antibody, Als2 antibody
    背景
    ALS2 specifically binds to, and functions as a guanine nucleotide exchange factor (GEF) for the small GTPase RAB5. ALS2 contains an ATS1/RCC1-like domain, a RhoGEF domain, and a vacuolar protein sorting 9 (VPS9) domain, all of which are guanine-nucleotide exchange factors that activate members of the Ras superfamily of GTPases. The protein localizes with RAB5 on early endosomal compartments, and functions as a modulator for endosomal dynamics. Loss of ALS2 function might underlie neuronal dysfunction and degeneration in a number of motor neuron diseases.Synonyms: ALS2CR6, Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 6 protein, Amyotrophic lateral sclerosis protein 2, KIAA1563
    基因ID
    57679
    NCBI登录号
    NP_065970
    UniProt
    Q96Q42
    途径
    Skeletal Muscle Fiber Development
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