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SOCS3 抗体 (C-Term)

SOCS3 适用: 人, 小鼠, 大鼠, Cow, Pig, 犬 WB 宿主: 山羊 Polyclonal unconjugated
产品编号 ABIN374066
发货至: 中国
  • 抗原 See all SOCS3 抗体
    SOCS3 (Suppressor of Cytokine Signaling 3 (SOCS3))
    抗原表位
    • 17
    • 5
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    适用
    • 48
    • 35
    • 30
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    人, 小鼠, 大鼠, Cow, Pig, 犬
    宿主
    • 55
    • 18
    • 1
    山羊
    克隆类型
    • 57
    • 17
    多克隆
    标记
    • 41
    • 11
    • 7
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    This SOCS3 antibody is un-conjugated
    应用范围
    • 47
    • 29
    • 19
    • 7
    • 7
    • 6
    • 4
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB)
    序列
    C-PIREFLDQYD APL
    特异性
    This antibody detects SOCS3 at C-term.
    交叉反应 (详细)
    Species reactivity (expected):Mouse, Rat, canine (Dog), Pig, Cow.
    Species reactivity (tested):Human.
    纯化方法
    Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide
    免疫原
    Peptide with sequence from the C Terminus of the protein sequence according to NP_003946.3. Genename: SOCS3
    Top Product
    Discover our top product SOCS3 Primary Antibody
  • 应用备注
    ELISA: Limit dilution: 1/16000. Western Blot: 4-6 μg/mL. Approx 24 kDa band observed in MOLT-4 lysate.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    限制
    仅限研究用
  • 浓度
    0.5 mg/mL
    缓冲液
    Tris saline, pH 7.3 containing 0.02 % Sodium Azide and 0.5 % BSA
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid repeated freezing and thawing.
    储存条件
    4 °C/-20 °C
    储存方法
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • 抗原
    SOCS3 (Suppressor of Cytokine Signaling 3 (SOCS3))
    别名
    SOCS3 / CIS3 (SOCS3 产品)
    别名
    socs3 antibody, fj09e12 antibody, zgc:56537 antibody, wu:fj09e12 antibody, MGC64393 antibody, MGC75749 antibody, xsocs3 antibody, MGC81248 antibody, atod4 antibody, cis3 antibody, cish3 antibody, socs-3 antibody, ssi-3 antibody, ssi3 antibody, SOCS3 antibody, ATOD4 antibody, CIS3 antibody, Cish3 antibody, SOCS-3 antibody, SSI-3 antibody, SSI3 antibody, Cis3 antibody, EF-10 antibody, Ef10 antibody, Ssi3 antibody, Socs-3 antibody, Ssi-3 antibody, suppressor of cytokine signaling 3a antibody, suppressor of cytokine signaling 3 S homeolog antibody, suppressor of cytokine signaling 3 antibody, suppressor of cytokine signaling 3 L homeolog antibody, socs3a antibody, socs3.S antibody, socs3 antibody, socs3.L antibody, SOCS3 antibody, Socs3 antibody
    背景
    Accumulating evidence demonstrates that cytokine receptor signaling is negatively regulated by a family of Src homology 2 domain-containing adaptor molecules Termed SOCS (Suppressor of Cytokine Signaling). To date, there are eight members of SOCS family have been recognized, they are SOCS-1, 2, 3, 4, 5, 6, 7 and CIS. Structurally the SOCS proteins are composed of an N-terminal region of variable length and amino acid composition, a central SH2 domain, and a previously unrecognized C-terminal motif that we have called the SOCS box. The SOCS proteins appear to form part of a classical negative feed back loop that regulates cytokine signal transduction via a STAT-induced transcriptional mechanism. Transcription of each of the SOCS genes occurs rapidly in vitro and in vivo in response to cytokines, and once produced, the various members of the SOCS family appear to inhibit signaling in different ways.Synonyms: CIS-3, Cytokine-inducible SH2 protein 3, SOCS-3, SSI-3, SSI3, STAT-induced STAT inhibitor 3, Suppressor of cytokine signaling 3
    基因ID
    9021
    NCBI登录号
    NP_003946
    UniProt
    O14543
    途径
    JAK/STAT Signaling, Response to Growth Hormone Stimulus, Hepatitis C
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