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Tyrosine Hydroxylase 抗体 (pSer31)

TH 适用: 大鼠, 小鼠, Non-Human Primate WB, IF, IHC (fro) 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN372737
发货至: 中国
  • 抗原 See all Tyrosine Hydroxylase (TH) 抗体
    Tyrosine Hydroxylase (TH)
    抗原表位
    • 17
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    • 3
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    • 1
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    pSer31
    适用
    • 111
    • 106
    • 93
    • 11
    • 10
    • 8
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    • 3
    • 3
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    大鼠, 小鼠, Non-Human Primate
    宿主
    • 106
    • 25
    • 7
    • 4
    • 2
    克隆类型
    • 109
    • 35
    多克隆
    标记
    • 93
    • 8
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
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    • 1
    This Tyrosine Hydroxylase antibody is un-conjugated
    应用范围
    • 99
    • 67
    • 38
    • 22
    • 21
    • 18
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    • 6
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    Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Frozen Sections) (IHC (fro))
    特异性
    Specific for the ~60k tyrosine hydroxylase protein phosphorylated at Ser31.
    交叉反应 (详细)
    Species reactivity (expected):Non-Human Primates.
    Species reactivity (tested):Mouse and Rat.
    纯化方法
    Affinity Chromatography via Sequential Chromatography on phospho- and dephosphopeptide affinity columns.
    免疫原
    Phosphopeptide corresponding to amino acid residues surrounding phospho-Ser31 of rat Tyrosine Hydroxylase (TH).
    亚型
    IgG
    Top Product
    Discover our top product TH Primary Antibody
  • 应用备注
    Western blotting: 1/1,000. Immunofluorescence 1/1000 (Frozen Sections). Immunohistochemistry on Frozen Sections: 1/1000.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg/mL BSA and 50 % Glycerol.
    注意事项
    Avoid repeated freezing and thawing.
    储存条件
    -20 °C
    储存方法
    Store the antibody undiluted (in aliquots) at-20 °C.
  • Jedynak, Ali, Haycock, Hope: "Acute administration of cocaine regulates the phosphorylation of serine-19, -31 and -40 in tyrosine hydroxylase." in: Journal of neurochemistry, Vol. 82, Issue 2, pp. 382-8, (2002) (PubMed).

    Salvatore, Waymire, Haycock: "Depolarization-stimulated catecholamine biosynthesis: involvement of protein kinases and tyrosine hydroxylase phosphorylation sites in situ." in: Journal of neurochemistry, Vol. 79, Issue 2, pp. 349-60, (2001) (PubMed).

  • 抗原
    Tyrosine Hydroxylase (TH)
    别名
    Tyrosine 3-Monooxygenase (TH) (TH 产品)
    别名
    DYT14 antibody, DYT5b antibody, TYH antibody, The antibody, CG10118 antibody, DH65B antibody, DTH antibody, Dmel\\CG10118 antibody, Pale antibody, Ple antibody, TH antibody, Th antibody, VII antibody, dTH1 antibody, dTH65B antibody, pale/ple antibody, th antibody, dyt14 antibody, dyt5b antibody, tyh antibody, tyrosine hydroxylase antibody, pale antibody, tyrosine 3-monooxygenase antibody, tyrosine hydroxylase S homeolog antibody, TH antibody, Th antibody, ple antibody, th antibody, th.S antibody, LOC100008895 antibody
    背景
    Tyrosine Hydroxylase (TH) is the rate-limiting enzyme in the synthesis of the catecholamines Dopamine and Norepinephrine. TH antibodies can therefore be used as markers for dopaminergic and noradrenergic neurons in a variety of applications including depression, schizophrenia, Parkinson's disease and drug abuse (Kish et al., 2001, Zhu et al., 2000, Zhu et al., 1999). TH antibodies can also be used to explore basic mechanisms of dopamine and norepinephrine signaling (Witkovsky et al., 2000, Salvatore et al., 2001, Dunkley et al., 2004). The activity of TH is also regulated by phosphorylation (Haycock et al., 1982, Haycock et al., 1992, Jedynak et al., 2002). Phospho-specific antibodies for the phosphorylation sites on TH can be used to great effect in studying this regulation and in identifying the cells in which TH phosphorylation occurs.Synonyms: TYH, Tyrosine 3-hydroxylase
    基因ID
    25085
    NCBI登录号
    NP_036872
    UniProt
    P04177
    途径
    Dopaminergic Neurogenesis, Response to Water Deprivation, Sensory Perception of Sound, Carbohydrate Homeostasis, Feeding Behaviour
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