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FADD 抗体 (Sepharose)

FADD 适用: 人 WB, IP, EIA 宿主: 小鼠 Monoclonal 1A11 Sepharose
产品编号 ABIN371639
发货至: 中国
  • 抗原 See all FADD 抗体
    FADD (Fas (TNFRSF6)-Associated Via Death Domain (FADD))
    适用
    • 87
    • 61
    • 19
    • 18
    • 15
    宿主
    • 98
    • 17
    小鼠
    克隆类型
    • 94
    • 21
    单克隆
    标记
    • 68
    • 6
    • 4
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    • 4
    • 3
    • 2
    • 2
    • 1
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    This FADD antibody is conjugated to Sepharose
    应用范围
    • 89
    • 51
    • 31
    • 15
    • 15
    • 15
    • 11
    • 9
    • 6
    • 5
    • 3
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    • 1
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    Western Blotting (WB), Immunoprecipitation (IP), Enzyme Immunoassay (EIA)
    特异性
    This antibody is specific for FADD.
    产品特性
    Synonyms: FAS-associated death domain protein, MORT1, GIG3, FAS-associating deathdomain-containing protein, Mediator of receptor induced toxicity, Growth-inhibiting gene 3protein
    克隆位点
    1A11
    亚型
    IgG1
    Top Product
    Discover our top product FADD Primary Antibody
  • 应用备注
    ELISA. Immunoprecipitation. Western Blot.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    限制
    仅限研究用
  • 缓冲液
    2 mLof 100 mM Borate buffered saline, pH 8.2. No preservatives or amine-containing buffer salts added
    储存条件
    4 °C/-20 °C
    储存方法
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Store protected from light. Avoid repeated freezing and thawing.
    Shelf life: one year from despatch.
    有效期
    12 months
  • 抗原
    FADD (Fas (TNFRSF6)-Associated Via Death Domain (FADD))
    别名
    FADD (FADD 产品)
    别名
    MORT1 antibody, Mort1/FADD antibody, Mort1 antibody, TNFRSF6 antibody, adaptor antibody, fadd antibody, mort1 antibody, xfadd antibody, Fas associated via death domain antibody, Fas (TNFRSF6)-associated via death domain antibody, Fas associated via death domain S homeolog antibody, Fas (tnfrsf6)-associated via death domain antibody, FADD antibody, Fadd antibody, fadd.S antibody, fadd antibody
    背景
    Fas-associated death domain (FADD, also known as MORT1) is an important apoptosis adapter molecule involved in the Fas-mediated cell death pathway. FADD associates with the intracellular domain of FAS (CD95/APO-1) through their respective C-terminal death domains (DD). The N-terminal region of FADD contains a death effectors domain (DED) which recruits and binds cytosolic proteins such as FLICE/caspase-8. The subsequent activation of FLICE by proteolytic cleavage leads to the activation of the caspase-mediated (ICE-related proteases) apoptotic cascade. Overexpression of FADD induces apoptosis which is inhibited by CrmA, a specific inhibitor of the interleukin-1a-converting enzyme. FADD has also been shown under certain circumstances to promote cell survival and proliferation. (Ref.1-6)Synonyms: FAS-associated death domain protein, FAS-associating death domain-containing protein, GIG3, Growth-inhibiting gene 3 protein, MORT1, Mediator of receptor induced toxicity
    基因ID
    8772
    UniProt
    Q13158
    途径
    Apoptosis, TLR signaling, Activation of Innate immune Response, Positive Regulation of Endopeptidase Activity, Toll-Like Receptors Cascades
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