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CBL 抗体 (AA 698-702)

CBL 适用: 人 IHC 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN363124
发货至: 中国
  • 抗原 See all CBL 抗体
    CBL (Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence (CBL))
    抗原表位
    • 28
    • 28
    • 26
    • 17
    • 9
    • 7
    • 7
    • 5
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 698-702
    适用
    • 170
    • 77
    • 65
    • 2
    • 2
    • 1
    • 1
    宿主
    • 150
    • 18
    • 3
    • 1
    克隆类型
    • 141
    • 31
    多克隆
    标记
    • 75
    • 9
    • 8
    • 8
    • 8
    • 8
    • 8
    • 8
    • 8
    • 6
    • 4
    • 4
    • 4
    • 4
    • 4
    • 2
    • 2
    • 2
    This CBL antibody is un-conjugated
    应用范围
    • 82
    • 52
    • 52
    • 49
    • 31
    • 25
    • 21
    • 16
    • 12
    • 10
    • 9
    • 3
    • 1
    • 1
    • 1
    Immunohistochemistry (IHC)
    特异性
    The antibody detects endogenous level of total c-Cbl protein.
    纯化方法
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography usingepitope-specific immunogen .
    免疫原
    Peptide sequence around AA 698-702 (T-E-Y-M-T) derived from Human c-Cbl. Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates.
    亚型
    IgG
    Top Product
    Discover our top product CBL Primary Antibody
  • 应用备注
    Western blotting: 1:500-1:1000
    Immunohistochemistry: 1:50-1:100
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 mg/mL
    缓冲液
    Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C/-20 °C
    储存方法
    Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
  • 抗原
    CBL (Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence (CBL))
    别名
    c-Cbl (CBL 产品)
    别名
    4732447J05Rik antibody, Cbl-2 antibody, c-Cbl antibody, cbl antibody, C-CBL antibody, CBL2 antibody, FRA11B antibody, NSLL antibody, RNF55 antibody, c-cbl-like antibody, RGD1561386 antibody, Casitas B-lineage lymphoma antibody, Cbl proto-oncogene antibody, Cbl antibody, CBL antibody
    背景
    Participates in signal transduction in hematopoietic cells. Adapter protein that functions as a negative regulator of many signaling pathways that start from receptors at the cell surface. Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Recognizes activated receptor tyrosine kinases, including PDGFA, EGF and CSF1, and terminates signaling.
    分子量
    120 kDa
    UniProt
    P22681
    途径
    TCR Signaling, Interferon-gamma Pathway, EGFR Signaling Pathway, EGFR Downregulation, VEGFR1 Specific Signals
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