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AKT 1/2/3 抗体 (AA 313-317)

适用: 人, 小鼠, 大鼠 IHC 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN363067
发货至: 中国
  • 抗原 See all AKT 1/2/3 products
    AKT 1/2/3
    抗原表位
    • 25
    • 23
    • 23
    • 23
    • 20
    • 20
    • 18
    • 18
    • 16
    • 16
    • 16
    • 7
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 313-317
    适用
    • 165
    • 153
    • 139
    • 46
    • 31
    • 28
    • 25
    • 15
    • 9
    • 6
    • 4
    • 4
    人, 小鼠, 大鼠
    宿主
    • 163
    • 2
    克隆类型
    • 152
    • 13
    多克隆
    标记
    • 42
    • 8
    • 8
    • 8
    • 8
    • 8
    • 8
    • 8
    • 8
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 2
    • 2
    • 2
    • 2
    • 2
    This AKT 1/2/3 antibody is un-conjugated
    应用范围
    • 148
    • 93
    • 92
    • 91
    • 36
    • 32
    • 29
    • 21
    • 9
    • 7
    • 6
    Immunohistochemistry (IHC)
    特异性
    The antibody detects endogenous level of total AKT1/AKT2/AKT3 protein.
    纯化方法
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography usingepitope-specific immunogen.
    免疫原
    Peptide sequence around AA 313-317, 314-318, 310-314 (P-E-Y-L-A) derived from Human AKT1, AKT2, AKT3. Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates.
    亚型
    IgG
  • 应用备注
    Immunohistochemistry: 1:50-1:100
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 mg/mL
    缓冲液
    Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C/-20 °C
    储存方法
    Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
  • 抗原
    AKT 1/2/3
    别名
    AKT1/AKT2/AKT3 (AKT 1/2/3 产品)
    背景
    General protein kinase capable of phosphorylating several known proteins. Phosphorylates TBC1D4. Signals downstream of phosphatidylinositol 3-kinase (PI3K) to mediate the effects of various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), insulin and insulin-like growth factor I (IGF-I). Plays a role in glucose transport by mediating insulin-induced translocation of the GLUT4 glucose transporter to the cell surface. Mediates the antiapoptotic effects of IGF-I. Mediates insulin-stimulated protein synthesis by phosphorylating TSC2 at 'Ser-939' and 'Thr-1462', thereby activating mTORC1 signaling and leading to both phosphorylation of 4E-BP1 and in activation of RPS6KB1. Promotes glycogen synthesis by mediating the insulin-induced activation of glycogen synthase. /General protein kinase capable of phosphorylating several known proteins. /IGF-1 leads to the activation of AKT3, which may play a role in regulating cell survival. Capable of phosphorylating several known proteins. Truncated isoform 2/PKB gamma 1 without the second serine phosphorylation site could still be stimulated but to a lesser extent.
    分子量
    60 kDa
    UniProt
    Q9Y243
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